If used early in infection, prophylactic treatment with the immunomodulatory drug cyclosporin A of Leishmania ma'or infected Balb/c mice has been shown to enhance resistance of these mice to serious disease. It is thought that CsA treatment affects disease progression by altering the balance of specific T lymphocyte populations as well as the secretion of various cytokines. We have followed the levels of L3T4+ T cells, Ly-2+ T cells, and total T and B lymphocytes, as well as IL-4 in susceptible Balb/c mice, CsA-treated Balb/c mice, and naturally resistant C57B1/6 mice during the course of L. ma'or infection. The CsA-treated mice displayed a disease pattern similar to that of the C57B1/6 group throughout infection. Most importantly, CsA treatment appeared to inhibit IL-4 production early post infection in both spleen and lymph node, and also appeared to inhibit the dramatic early increase of L3T4+ (CD4+) T cells which is characteristic of the susceptible Balb/c mice. / Department of Biology
| Identifer | oai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:handle/185399 |
| Date | January 1995 |
| Creators | Southern, Kristina L. |
| Contributors | Behforouz, Nancy C. |
| Source Sets | Ball State University |
| Detected Language | English |
| Format | iii, 93 leaves : ill. ; 28 cm. |
| Source | Virtual Press |
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