Type 1 diabetes mellitus (T1D) is an autoimmune disease that results in deficient production of insulin from pancreatic beta cells. In addition to glycemic control irregularities, T1D can have profound effects on other metabolic processes in the body. Of these, bone, muscle, and adipose tissue metabolism are of interest in the fields of bone density and fracture risk. When combined with a diagnosis of T1D, the lifetime risk of fracture is up to four times higher; however, the relative risk of fracture highest in adulthood. This is of concern as fractures later in life have been shown to have adverse consequences on overall health. Understanding how fat mass and lean mass affect fracture risk in participants with and without T1D has the potential to provide support for accurately predicting and managing this fracture risk. In this cross-sectional analysis of adolescent girls ages 9 -18 with and without T1D, both groups were well matched in most areas, and significant differences between the two groups were seen at body mass index (BMI), BMI Z-score, lean mass index (LMI), LMI Z-score, hemoglobin A1c (HbA1c), and parathyroid hormone (PTH). The calculated predicted force of fall and measured failure load at the distal radius were used to investigate the load-to-strength ratio (LSR). The LSR has the potential to be beneficial in directly assessing fracture risk. From the analysis, it is possible to propose more in-depth studies of the hypothesized positive and negative effects of fat mass and lean mass, respectively on fracture risks.
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/48211 |
| Date | 26 February 2024 |
| Creators | Fugate, Cheyenne Makayla |
| Contributors | Wisco, Jonathan, Mitchell, Deborah M. |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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