KS0365, a novel activator of the transient receptor potential vanilloid 3 (TRPV3) channel, accelerates keratinocyte migration

Description

KS0365 activated recombinant and native mouse TRPV3 more potently
and with a higher efficacy compared with 2-APB and did not activate TRPV2 or
TRPV4 channels. The activation of TRPV3 by KS0365 super-additively accelerated
the EGF-induced keratinocyte migration, which was inhibited by the TRP channel
blocker ruthenium red or by siRNA-mediated TRPV3 knockdown. Moreover, KS0365
induced strong Ca2+ responses in migrating front cells and in leading edges of keratinocytes.

Links & Downloads

1. urn:nbn:de:bsz:15-qucosa2-931713
2. https://ul.qucosa.de/id/qucosa%3A93171
3. https://ul.qucosa.de/api/qucosa%3A93171/attachment/ATT-0/

Tags

info:eu-repo/classification/ddc/610

ddc:610

Additional Fields

Identifer	oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:93171
Date	09 August 2024
Creators	Maier, Marion, Olthoff, Stefan, Hill, Kerstin, Zosel, Carolin, Magauer, Thomas, Wein, Lukas Anton, Schaefer, Michael
Publisher	Wiley
Source Sets	Hochschulschriftenserver (HSSS) der SLUB Dresden
Language	English
Detected Language	English
Type	info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text
Rights	info:eu-repo/semantics/openAccess
Relation	0007-1188, 1476-5381, 10.1111/bph.15937