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KS0365, a novel activator of the transient receptor potential vanilloid 3 (TRPV3) channel, accelerates keratinocyte migration

KS0365 activated recombinant and native mouse TRPV3 more potently
and with a higher efficacy compared with 2-APB and did not activate TRPV2 or
TRPV4 channels. The activation of TRPV3 by KS0365 super-additively accelerated
the EGF-induced keratinocyte migration, which was inhibited by the TRP channel
blocker ruthenium red or by siRNA-mediated TRPV3 knockdown. Moreover, KS0365
induced strong Ca2+ responses in migrating front cells and in leading edges of keratinocytes.

Identiferoai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:93171
Date09 August 2024
CreatorsMaier, Marion, Olthoff, Stefan, Hill, Kerstin, Zosel, Carolin, Magauer, Thomas, Wein, Lukas Anton, Schaefer, Michael
PublisherWiley
Source SetsHochschulschriftenserver (HSSS) der SLUB Dresden
LanguageEnglish
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text
Rightsinfo:eu-repo/semantics/openAccess
Relation0007-1188, 1476-5381, 10.1111/bph.15937

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