Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2014-08-05T11:56:01Z
No. of bitstreams: 2
license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)
ludimilacardoso.pdf: 1127107 bytes, checksum: fb1d15343c99566085805dabb23209ad (MD5) / Made available in DSpace on 2014-08-05T11:56:01Z (GMT). No. of bitstreams: 2
license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)
ludimilacardoso.pdf: 1127107 bytes, checksum: fb1d15343c99566085805dabb23209ad (MD5)
Previous issue date: 2006 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / The development of a Th1 immune response is the key event to prevent Leishmania
infection and is linked with the IL-12 production by monocytes, dendritic cells,
macrophages and neutrophils. The IL-12 signal induces the increase of IFN-γ
production by T cells, favoring the profile of the Th1 immune response and the
resistance phenotype to the infection. In the vertebrate host, the leishmania inhabits in
cells of the mononuclear phagocyte system (MPS), which is also responsible for the
elimination of the parasite. The participation of immature cells of MPS in the initial
production of IL-12 has been discussed. It was demonstrated recently that a
population of mononuclear phagocytes, derived from bone marrow culture and
expressing the marker ER-HR3 produced great amount of IL-12p40 after stimulation in
vitro with procyclic or metacyclic promastigotes of L. (L.) major. The initial production
of IL-12 by MPS cells is under investigation. It is unclear the role of mononuclear
phagocytes, in different stages of maturation, in the production of
IL-12p40 in vivo. In this work, we evaluated the involvement of MPS cells, in different
stage of maturation, with the IL-12p40 production in vivo in draining lymph nodes of
BALB/c mice after 48 h of infection with L. (L.) major. Our results showed that CD31+
cells (mononuclear phagocytes precursors) were absent in the draining lymph nodes
of the subcutaneously footpad injection and that the number of ER-MP58+
(immature mononuclear phagocytes), ER-HR3+ cells (mononuclear phagocytes in the intermediate stage of maturation) and 33D1+
(mature phagocytes) increase in the period of 48 h after infection. We showed, also, that ER-MP58+
responsible for great part of the draining lymph nodes IL-12 production 48 h after
infection with stationary-phase promastigotes of L. (L.) major in mice BALB/c. We
suggested that, in vivo, the ER-MP58+ population, together with other cellular
populations, known as IL-12 producers, ER-MP58+ cell has an important role in the inflammation induced by the parasitic inoculum. / O desenvolvimento de uma resposta imune do tipo Th1 é o evento chave para
prevenir a infecção murina por Leishmania e está interligada à produção de IL-12 por
monócitos, células dendríticas, macrófagos e neutrófilos. A sinalização via IL-12
aumenta a produção de IFN-γ por células T, favorecendo o perfil Th1 da resposta
imune e o fenótipo de resistência à infecção. A leishmania, no hospedeiro vertebrado,
reside em células do sistema fagocítico mononuclear (SFM), o qual também é
responsável pela eliminação do parasito. A participação de células indiferenciadas do
SFM na produção de IL-12 vem sendo discutida. Foi demonstrado recentemente que
uma população de fagócitos mononucleares, derivados de cultura de medula óssea e
expressando o marcador ER-HR3 produzia grande quantidade de IL-12p40 após
estimulação in vitro com formas procíclicas ou metacíclicas de L. (L.) major. A
produção de IL-12 na infecção por L. (L.) major por fagócitos em diferentes estágios
de maturação in vivo ainda não está claro. Neste trabalho, avaliamos o envolvimento
de células em diferentes estágios de maturação em linfonodos drenantes após 48 h
de infecção por L. (L.) major em camundongos BALB/c, quanto à produção de IL-
12p40. Verificamos que células CD31+ (precursores de fagócitos mononucleares)
estão ausentes nos linfonodos drenantes do sítio do inóculo e que o número de células ER-HR3+ (fagócitos mononucleares em estágio intermediário de maturação), células ER-MP58+ (fagócitos imaturos) e 33D1+ (subpopulações de células dendríticas) aumenta no período de 48 h após a infecção. Mostramos também que,
células ER-MP58+ são as principais responsáveis por grande parte da produção de
IL-12 nos linfonodos drenantes 48 h após a infecção por L. (L.) major em
camundongos BALB/c. Sugerimos que, in vivo, a população ER-MP58+
com as outras populações celulares, conhecidas como produtoras de IL-12, têm um
papel relevante na inflamação induzida pelo inóculo parasitário.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.bc.ufg.br:tde/2879 |
| Date | January 2006 |
| Creators | Cardoso, Ludimila Paula Vaz |
| Contributors | Oliveira, Milton Adriano Pelli de, Lima, Glória Maria Collet de Araújo |
| Publisher | Universidade Federal de Goiás, Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP), UFG, Brasil, Faculdade de Medicina - FM (RG) |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFG, instname:Universidade Federal de Goiás, instacron:UFG |
| Rights | http://creativecommons.org/licenses/by-nc-nd/4.0/, info:eu-repo/semantics/openAccess |
| Relation | 1102159680310750095, 600, 600, 600, 600, 306626487509624506, -969369452308786627, 2075167498588264571, Afonso LC, Scharton TM, Vieira LQ, Wysocka M, Trinchieri G, Scott P 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science. 14. 263 (5144):235-7. Alexander J, Russell D G 1992. The interaction of Leishmania species with macrophages. Adv Parasitol. 31:175-254. Alexander J, Bryson K 2005. T helper (h)1/Th2 and Leishmania: paradox rather than paradigm. Immunology Letters. 99: 17-23. Andrew, SM & Titus JA 1997. Purification and fragmentation of antibodies. In Current Protocols in Immunology. Coligan JE., Kruisbeek AM., Margulies DH., Shevach EM., Strober W. (ed). Wiley J and Sons. New York. 2.7.1–2.7.12. Ashford RW, Desjeux P, deRaadt P 1992. Estimation of population at risk of infection and number of cases of leishmaniasis. Parasitol Today. 8 (3): 104-105. Baccarini M, Hockertz S, Kiderlen AF, Lohmann-Matthes ML 1988. Extracellular killing of Leishmania promastigotes and amastigotes by macrophage precursors derived from bone marrow cultures. J Exp Med. 167:1486-1492. Banchereau J, Steinman RM 1998. Dendritic cells and the control of immunity. Nature. 392 (6673): 245-252. Bailey H, Bishop WJ 1959. Leishman-Donovan bodies and donovaniasis; Sir William Boog Leishman, 1865-1926; Charles Donovan, 1863-1951. Br J Vener Dis. 35:8-9. Bastos KR, Marinho CR, Barboza R, Russo M, Alvarez JM, D'Imperio Lima MR 2004. What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells? Microbes Infect. 6(6):630-6. Belazzoug S 1992. Leishmaniasis in Mediterranean countries. Vet Parasitol. 44: 15-9. Biedermann T, Zimmermann S, Himmelrich H, Gumy A, Egeter O, Sakrauski A K, Seegmüller I, Voigt H, Launois P, Levine A D, Wagner H, Klaus Heeg K, Louis J A, Röcken M 2001. IL-4 instructs Th1 responses and resistance to Leishmania major in susceptible BALB/c mice. Nature Immunology. 2 (11):1054-60. Bosque F, Belkaid Y, Briend E, Hevin B, Lebastard M, Soussi N, Milon G 1997. The biology of macrophages. Pathol Biol. 45:103-109. -Referências Bibliográficas de acordo com as normas da revista Memórias do Instituto 1 Oswaldo Cruz. Bryceson A 1996. Leishmaniasis. In: Cokk G (Ed) Manson's Tropical Diseases. ed. London: Saunders, 1213-1246. Carrera L, Gazzinelli RT, Badolato R, Hieny S, Muller W, Kuhn R, Sacks DL 1996. Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow- derived macrophages from susceptible and resistant mice. J. Exp. Med.183 (2).515- 26. Carson WE, Ross ME, Baiocchi RA, Marien MJ, Boiani N, Grabstein K, Caligiuri MA 1995. Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro. J Clin Invest. 96 (6). 2578-82. Chakir H, Campos-Neto A, Mojibian M, Webb JR 2003. IL-12Rbeta2-deficient mice of a genetically resistant background are susceptible to Leishmania major infection and develop a parasite-specific Th2 immune response. Microbes Infect. 5 (4): 241-9. Chan J, Leenen PJ, Bertoncello I, Nishikawa SI, Hamilton JA 1998. Macrophage lineage cells in inflammation: characterization by colony- stimulating factor-1 (CSF-1) receptor (c-Fms), ER-MP58, and ER-MP20 (Ly- 6C) expression. Blood. 92 (4). 1423- 31. D'Andrea A, Rengaraju M, Valiante NM, Chehimi J, Kubin M, Aste M, Chan SH, Kobayashi M, Young D, Nickbarg E 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclearncells. J Exp Med. 5: 1387-98. Da Silva R, Sacks DL 1987. Metacyclogenesis is a major determinant of Leishmania promastigote virulence and attenuation. Infect. Immun. 55 (11). 2802-2806. De Bruijn MF, Ploemacher RE, Mayen AE, Voerman JS, Slieker WA, Van Ewijk W, Leenen PJ 1996. High-level expression of the ER-MP58 antigen on mouse bone marrow hematopoietic progenitor cells marks commitment to the myeloid lineage. Eur J Immunol. 26 (12):2850-8. De Jong JP, Voerman JS, Van Der Sluijs-Gelling AJ, Willemsen R, Ploemacher RE 1994a. A monoclonal antibody (ER-HR3) against murine macrophages. I. Ontogeny, distribution and enzyme histochemical characterization of ER-HR3-positive cells. Cell Tissue Res. 275 (3), 567-76. De Jong JP, Leenen PJ, Voerman JS, van der Sluijs-Gelling AJ, Ploemacher RE 1994b. A monoclonal antibody (ER-HR3) against murine macrophages. II. Biochemical and functional aspects of the ER-HR3 antigen. Cell Tissue Res. 275 (3): 577-85. Denkers EY, Del Rio L, Bennouna S 2003. Neutrophil production of IL-12 and other cytokines during microbial infection. Chem Immunol Allergy.83: 95-114. Desjeux P 1996. Leismaniasis: puplic health aspects and control. Clinical Dermatology 14: 417-423. Dickerhoff R, Muller A, Bode U 1990. Visceral leishmaniasis. Personal observation and review of epidemiology, clinical aspects and therapy. Klin Padiatr. 202 (5): 347- 51. Doherty TM, Coffman RL 1999. Ability of macrophage subsets to transfer resistance to murine leishmaniasis is dependent on IL-12 production. Eur J Immunol. 29:522-529. Ehrchen J, Sindrilaru A, Grabbe S, Schonlau F, Schlesiger C, Sorg C, Scharffetter- Kochanek K, Sunderkotter C 2004. Senescent BALB/c mice are able to develop resistance to Leishmania major infection. Infect Immun. 72:5106-5114. Evans D, Godfrey D, Lanham S, Lanotte G, Modabber F, Schnur L 1989. Handbook on isolation, characterization and cryopreservation of Leishmania. UNDP/World Bank/WHO, Special Programme for Research and Training in Tropical Diseases (Edited by: Evans D). 1-45. Evans TG 1993. Leishmaniasis. Infect Dis Clin North Am. 7 (3): 527-46. Farah FS, Samra AS, Nuwayri-Salti N 1975. The role of macrophage in cutaneous leishmaniasis. Immunology. 29 (4) 755-64. Faust EC, Russel PF, Jung RC 1974. Parasitologia Clínica. Ed: México: Salvat S.A. 888. Felizardo TC 2005. Influência do sítio de inoculação na evolução da doença e da resposta imune na infecção experimental por Leishmania (L.) amazonensis. (Tese de Doutorado). Departamento de Imunologia da Universidade de São Paulo. Geutskens SB, Otonkoski T, Pullknen MA, Drexhage HA, Leenen PJ 2005. Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro. J Leukoc. Biol. 78 (4):845-52. Gontijo B, De Carvalho MDE, L 2003. American Cutaneous Leishmaniasis. Soc Bras Med Trop. 36: 71-80. Gorak PM, Engwerda CR, Kaye PM 1998. Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection. Eur J Immunol. 28(2):687-95. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity 2005. Nat Rev Immunol. 5 (12): 953-64. Guler ML, Gorham JD, Hsieh CS, Mackey AJ, Steen RG, Dietrich WF,Murphy KM 1996. Genetic susceptibility to Leishmania: IL-12 responsiveness in Th1 cell development. Science. 271 (5251) 16. 984-7. Heath VL, Showe L, Crain C, Barrat FJ, Trinchieri G, O'Garra A 2000. Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma. The Journal of Immunology. 164 (6):2861-5. Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM 1989. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med. 169 (1). 59-72. Heinzel FP, Schoenhaut DS, Rerko RM, Rosser LE, Gately MK 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177 (5). 1505- 9. Hendriks HR, Eestermans IL, Hoefsmit EC 1980. Depletion of macrophages and disappearance of postcapillary high endothelial venules in lymph nodes deprived of afferent lymphatic vessels. Cell Tissue Res. 211:375-389. Henri S, Curtis J, Hochrein H, Vremec D, Shortman K, Handman E 2002. Hierarchy of susceptibility of dendritic cell subsets to infection by Leishmania major: inverse relationship to interleukin-12 production. Infect Immun. 70:3874-3880. Henry JB. Diagnostico clinico e tratamento por métodos laboratoriais. São Paulo: Manole. 1996. 18o Herouet C, Cottin M, Galanaud P, Leclaire J, Rousset F 1999. Contact sensitizers decrease 33D1 expression on mature Langerhans cells. Eur. J. Dermatol. 9: 185-190. Herwaldt BL 1999. Leishmaniasis. The Lancet. 354: 1191-1199. Himmelrich H, Lopez CP, Tacchini-Cottier F, Louis A, Launois P 1998. The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor β2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12. The Journal of Immunology. 161 (11):6156-63. Hoare CA 1938. Early discoveries regarding the parasite of oriental sore (with an English translation of the memoir by P.F. Borovsky: “On sart sore”. 1989). Trans. R. Soc. Trop. Med. Hyg. 32: 67-92. Honigberg BM, Balamuth W, Bovee EC, Corliss JO, Gojdics M, Hall RP, Kudo RR, Levine ND, Loeblich AR JR, Weiser J, Wenrich DH 1964. A Revised Classification of the Phylum Protozoa. J Protozool.11: 7-20. ed. 1218 – 1226. Hume DA, Ross IL, Himes SR, Sasmono RT, Wells CA, Ravasi T 2002. The mononuclear phagocyte system revisited. J Leukoc Biol. 72 (4):621-7. Jankovic D, Sher A, Yap G 2001. Th1/Th2 effector choice in parasitic infection: decision making by committee. Curr Opin Immunol. 13 (4). 403-9. Kane MM, Mosser DM 2000. Leishmania parasites and their ploys to disrupt macrophage activation. Curr Opin Hematol. 7 (1): 26-31. Kennedy DW, Abkowitz JL 1998. Mature monocytic cells enter tissues and engraft. Proc Natl Acad Sci. 8; 95 (25):14944-9. Killick-Kendrick R, Molyneux DH 1981. Transmission of leishmaniasis by the bite of phletomine sandflies: Possible mechanismms. Trans R Soc Trop Med Hyg. 75 (1): 152-4. Klaus 1987. Lymphocytes. A practical approach, Edited by G G B Klaus. IRL press. Laskay T, Wittmann I, Diefenbach A, Rollinghoff M, Solbach W 1997. Control of Leishmania major infection in BALB/c mice by inhibition of early lymphocyte entry into peripheral lymph nodes. J. Immunol.158 (3).1246-53. Launois P, Maillard I, Pingel S, Swihart KG, Xenarios I, Acha-Orbea H, Diggelmann H, Locksley RM, Macdonald HR, Louis JA 1997. IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity. 6 (5). 541-9. Leenen PJ, Slieker WA, Melis M, Van Ewijk W 1990. Murine macrophage precursor characterization. I. Production, phenotype and differentiation of macrophage precursor hybrids. Eur J Immunol. 20 (1), Jan.15-25. Leenen PJ, De Bruijn MF, Voerman JS, Campbell PA, Van Ewijk W 1994. Markers of mouse macrophage development detected by monoclonal antibodies. J. Immunol. Methods.174 (1-2). 5-19. Leenen P J, Radosevic K, Voerman J S, Salomon B, Van Rooijen N, Klatzmann D, Van Ewijk W 1998. Heterogeneity of mouse spleen dendritic cells: in vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover. J. Immunol.160 (5).2166-73. Leite G 1958. Leishmaniasis visceral. I. Introduction, history & epidemiology. Rev Bras Med.15 (9): 605-10. Liew FY,O'donnell CA 1993. Immunology of leishmaniasis. Adv. Parasitol. 32.161- 259. Lima HC, Bleyenberg JA, Titus RG 1997. A simple method for quantifying Leishmania in tissues of infected animals. Parasitol Today.13 (2).80-2. Ling V, Luxenberg D, Wang J, Nickbarg E, Leenen PJ, Neben S, Kobayashi M 1997. Structural identification of the hematopoietic progenitor antigen ER-MP12 as the vascular endothelial adhesion molecule PECAM-1 (CD31). Eur J Immunol. 27 (2): 509-14. Locksley RM, Heinzel FP, Fankhauser JE, Nelson CS, Sadick MD 1998. Cutaneous host defense in leishmaniasis: interaction of isolated dermal macrophages and epidermal Langerhans cells with the insect-stage promastigote. Infect Immun. 56 (2): 336-42. Macatonia NA, Hosken M, Litton P, Vieira CS, Hsieh JÁ, Culpepper M, Wysocka G, Trinchieri KM, Murphy, O’Garra 1995. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J. Immunol. 154: 5071-5079. Marzochi MC, Marzochi KB 1994. Tegumentary and visceral leishmaniases in Brazil: emerging anthropozoonosis and possibilities for their control. Cad Saude Publica. 10 Suppl. 2: 359-75. Mauel J 1996. Intracellular survival of protozoan parasites with special reference to Leishmania spp., Toxoplasma gondii and Trypanosoma cruzi. Adv Parasitol. 38. 1-51. Mcknight AJ, Gordon S 1998. Membrane molecules as differentiation antigens of murine macrophages. Adv. Immunol. 68. 271-314. Mirkovich, Galelli, Allison, Modabber 1986. Increased myelopoiesis during Leishmania major infection in mice: generation of ‘safe targets,’ a possible way to evade the effector immune mechanism. Clin. Exp. Immunol. 64:1-7. Moll H, Fuchs H, Blank C, Rollinghoff M 1993. Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen- specific T cells. Eur J Immunol 23: 1595-601. Morelli AE, Zahorchak AF, Larregina AT, Colvin BL, Logar AJ, Takayama T, Falo LD, Thomson AW 2001. Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation. Blood. 1;98 (5): 1512-23. Moser M 2001. Regulation of Th1/Th2 development by antigen-presenting cells in vivo. Immunobiology. 204 (5):551-7; Moser M, Murphy KM 2000. Dendritic cell regulation of TH1-TH2 development. Nat Immunol. 1 (3):199-205. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL 1986. Two types of murine helper T cell clone. J Immunol 136 (7): 2348-2357. Mosmann TR & Sad S 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunology Today.17(3): 142-156. Muller-Berghaus J, Olson WC, Moulton RA, Knapp WT, Schadendorf D, Storkus WJ 2005. IL-12 production by human monocyte-derived dendritic cells: looking at the single cell. J Immunother. 28 (4): 306-13. Nishikomori R, Ehrhardt RO, Strober W 2000. T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor beta 2 chain expression and signaling. J Exp Med. 191 (5):847-58. Nishikomori R, Gurunathan S, Nishikomori K, Strober W 2001. BALB/c mice bearing a transgenic IL-12 receptor beta 2 gene exhibit a nonhealing phenotype to Leishmania major infection despite intact IL-12 signaling. J Immunol. 166 (11). 6776-83. Nunes A 2003. O papel das células dendríticas nas infecções murinas por Leishmania major ou Leishmania amazonensis. (Dissertação de Mestrado). Departamento de Imunologia da Universidade de São Paulo. Nussenzweig MC, Steinman RM, Witmer MD, Gutchinov B 1982. A monoclonal antibody specific for mouse cells. Proc. Natl. Acad. Sci. 79: 161-169. Oliveira MA, Lima GM, Shio MT, Leenen PJ, Abrahamsohn IA 2003. Immature macrophages derived from mouse bone marrow produce large amounts of IL-12p40 after LPS stimulation. J. Leukoc. Biol.74 (5), 857-67. Oliveira MA, Santiago HC, Lisboa CR, Ceravollo IP, Trinchieri G, Gazzinelli RT, Vieira LQ 2000. Leishmania sp: comparative study with Toxoplasma gondii and Trypanosoma cruzi in their ability to initialize IL-12 and IFN-gamma synthesis. Exp. Parasitol. 95 (2). 96-105. Oliveira MA, Tadokoro CE, Lima GM, Mosca T, Vieira LQ, Leenen PJ, Abrahamsohn IA 2005. Macrophages at intermediate stage of maturation produce high levels of IL- 12 p40 upon stimulation with Leishmania. Microbes Infect. 7 (2): 213-23. Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams JS, Moore KW, Rennick D, de Waal-Malefyt R, Hannum C, Bazan JF, Kastelein RA 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar s well as distinct from IL-12. Immunity. 13 (5): 715-25. Palframan RT, Jung S, Cheng G, Weninger W, Luo Y, Dorf M, Littman DR, Rollins BJ, Zweerink H, Rot A, von Andrian UH 2001. Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J Exp Med. 5; 194 (9): 1361-73. Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F, To W, Wagner J, O'Farrell AM, McClanahan T, Zurawski S, Hannum C, Gorman D, Rennick DM, Kastelein RA, de Wall MR, Moore KW 2002. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol. 1.168 (11):5699-708. Park AY, Hondowicz B, Kopf M, Scott P 2002. The role of IL-12 in maintaining resistance to Leishmania major. J. Immunol.168 (11). 5771-7. Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu CY, Gately MK, Gubler U. Related Articles 1996. A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci. 26;93 (24):14002-7. Qu C, Edwards EW, Tacke F, Angeli V, Llodra J, Sanchez-Schmitz G, Garin A, Haque NS, Peters W, van Rooijen N, Sanchez-Torres C, Bromberg J, Charo IF, Jung S, Lira SA, Randolph GJ 2004. Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J Exp Med. 200: 1231-1241. Randolph GJ, Inaba K, Robbiani DF, Steinman RM, Muller WA 1999. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity. 11: 753-761. Rey L 1991. Leishmania e leishmanioses: os parasitos. Parasitologia. Ed. Rio de Janeiro: Guanabara Koogan SA. 182-192. Ria F, Penna G, Adorini L 1998. Th1 cells induce and Th2 inhibit antigen-dependent IL-12 secretion by dendritic cells. Eur J Immunol. 28(6):2003-16. Robinson D, Shibuya K, Mui A, Zonin F, Murphy E, Sana T, Hartley SB, Menon S, Kastelein R, Bazan F,O'garra A 1997. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB. Immunity. 7 (4). 571-81. Rogers KA, DeKrey GK, Mbow ML, Gillespie RD, Brodskyn CI, Titus RG 2002 Type 1 and type 2 responses to Leishmania major. Microbiol Lett. 19; 209 (1):1-7. Sacks D, Anderson C 2004. Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice. Immunol Rev. 201: 225-38. Sacks D, Noben-Trauth N 2002. The immunology of susceptibility and resistance to Leishmania major in mice. Nature Ver immunol 2: 845-858. Sacks DL, Hieny S, Sher A 1985. Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes. J. Immunol.135 (1) 564-9. Saha B, Saini A, Germond R, Perrin PJ, Harlan DM, Davis TA 1999. Susceptibility or resistance to Leishmania infection is dictated by the macrophages evolved under the influence of IL-3 or GM-CSF. Eur J Immunol. 29:2319-2329. Santos MSTB 2005. Avaliação das células GR1+ murinas na resposta inata a Leishmania major. (Dissertação de Mestrado). Departamento de Microbiologia, Imunologia, Parasitologia e Patologia, Universidade Federal de Goiás. Scapini P, Lapinet-Vera JA, Gasperini S, Calzetti F, Bazzoni F, Cassatella MA 2000. The neutrophil as a cellular source of chemokines. Immunol Rev. 177:195-203. Scharton TM, Scott P 1993. Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice. J Exp Med. 178 (2). 567-77. Scharton-Kersten T, Afonso LC, Wysocka M, Trinchieri G, Scott P 1995. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 154 (10). 5320-30. Scott P 1989. The role of Th1 and Th2 cells in experimental cutaneous Leishmaniasis. Experimental Parasitology. 68 (3):369-72. Seder RA 1996. High-dose IL-2 and IL-15 enhance the in vitro priming of naive CD4+ T cells for IFN-gamma but have differential effects on priming for IL-4. J Immunol. 156 (7).1. 2413-22. Serarcangeli C, Pennica A 1996. Testimonies of an autochthonous illness on the anthropomorphic pottery in ancient Peru. Med Secoli. 8:125-141. Shaw JJ. Taxonomy of the genus Leishmania: present and future trends and their implications 1994. Mem Inst Oswaldo Cruz, 89: 471-478. Solbach W, Laskay T 2000. The host response to Leishmania infection. Adv. Immunol. 74. 275-317. Stafford JL, Neumann NF, Belosevic M 2002. Macrophage-mediated innate host defense against protozoan parasites. Crit Rev Microbiol 28: 187-248. Stobie L, Gurunathan S, Prussin C, Sacks DL, Glaichenhaus N, Wu CY,Seder RA 2000. The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge. Proc. Natl. Acad. Sci. U. S. A. 97 (15). 8427-32. Sunderkötter C, Nikolic T, Dillon M, Van Rooijen N, Stehling M, Drevets D, Leenen P 2004. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J. Immunol. 172 (7):4410-7. Sypek JP, Chung CL, Mayor SE, Subramanyam JM, Goldman SJ, Sieburth DS, Wolf SF,Schaub RG 1993. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177 (6). 1797-802. Taswell C 1986. Cell separation: selected methods and applications. In Pretlow TG, Pretlow TP (Eds.) Limiting dilution assays for the separation, characterization and quantification of biologically active particles and their clonal progeny: statistical methods for LDAs used by ELIDA. Academic Press, New York, 109-145. Trinchieri G & Gerosa F 1996. Immunoregulation by interleukin-12. Journal of Leukocyte Biology. 59 (4):505-11. Trinchieri G 1998. Interleukin-12: a cytokine at the interface of inflamation and immunity. Adv. Immunol. 70: 83-243. Turpin JA, Lopez-Berestein G 1992. Differentiation, maturation, and activation of monocytes and macrophages: functional a activity is controlled by a continuum of maturation. In: G. Lopez-Berestein e K. J. (Ed.). Mononuclear Phagocytes in Cell Biology. Boca Raton: CRC Press 71-99. von Stebut E, Belkaid Y, Jakob T, Sacks DL, Udey MC 1998. Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin- derived dendritic cells: implications for the initiation of anti-Leishmania immunity. J Exp Med. 19; 188 (8):1547-52. WHO 1998. Information by topic or disease: leishmaniasis. http://www.who.int/tdr/diseases/leish/default.htm. Williams RO 1988. Invasion of murine dendritic cells by Leishmania major and Leishmania mexicana mexicana. J Parasitol. 74(1):186-7. |
Page generated in 0.0042 seconds