Return to search

The synthesis and biological evaluation of d-myo-inositol 1,4,5-trisphosphate receptor ligands

The intracellular second messenger InsP₃ is a vital molecule in the regulation of Ca²⁺ signalling. Ca²⁺ mediates a wide range of cellular activities from fertilisation and cell differentiation through to apoptoisis. Using X-ray crystal structure data and molecular modelling, a series of novel InsP₃ analogues were designed as selective InsP₃R-antagonists. Two novel synthetic routes have been developed for the synthesis of these analogues. The first route uses a Ferrier-II rearrangement to provide enantiopure inositol intermediates, whereas, the second route employs a diastereomeric resolution to obtain the enantiopure inositols. The successful synthesis of InsP₃ and a series of 5-position modified analogues are reported herein.

Identiferoai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:552360
Date January 2010
CreatorsKeddie, Neil S.
ContributorsConway, Stuart J.
PublisherUniversity of St Andrews
Source SetsEthos UK
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Sourcehttp://hdl.handle.net/10023/963

Page generated in 0.0018 seconds