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Previous issue date: 2012-08-30 / The aim of this study was to assess, in vivo, the effect of two different surface treatments of titanium implants - plasma-spray (PSA) and nano-textured plasma-spray (PSA-nano) - at the bone-to-implant interface (osseointegration), associated or not to the recombinant human growth hormone (rhGH). Twenty-four prototypes of pure titanium implants, 6-mm long and 2-mm wide, were especially fabricated in a cylindrical shape and placed in 12 New Zealand rabbit s tibiae. The implants were divided into four groups: 1) PSA implants without rhGH, 2) PSA implants with rhGH, 3) PSA-nano implants without rhGH and, lastly, 4) PSA-nano implants with rhGH. The animals were sacrificed 14 and 42 after the surgeries. Samples were collected and analysed by optical microscopy (OM), scanning electronic microscopy (SEM) and infrared microscopy (μ-FTIR), besides the pull-out mechanical test. The results showed that in the early stage of osseointegration, the recombinant human growth hormone has favored new bone formation, regardless the surface treatment. Howev-er, in the later stage, the nano-textured surface, even without the hormone, has made a positive influence on the new bone formation, when compared to its use with hormone. In this stage, only the plasma-spray surface (PSA) has been favored by the growth hormone / O objetivo deste trabalho foi avaliar, in vivo, o efeito de dois diferentes trata-mentos de superf?cie de implantes de tit?nio - plasma-spray (PSA) e plasma-spray nanotexturizado (PSA-nano) - na interface osso-implante (osseointegra??o), associ-ados ou n?o ao horm?nio do crescimento humano recombinante (rhGH). Vinte e quatro prot?tipos de implantes de tit?nio puro, medindo 6 mm de comprimento por 2 mm de di?metro, foram especialmente confeccionados em uma forma cil?ndrica e colocados na t?bia de 12 coelhos da ra?a New Zealand. Os implantes foram dividi-dos em quatro grupos: 1) implantes PSA sem rhGH, 2) implantes PSA com rhGH, 3) implantes PSA-nano sem rhGH e, por ?ltimo, 4) implantes PSA-nano com rhGH. Os animais foram sacrificados 14 e 42 dias ap?s as cirurgias. As amostras foram cole-tadas e analisadas por microscopia ?ptica (MO), microscopia eletr?nica de varredura (MEV) e microscopia de infravermelho (μ-FTIR), al?m do teste mec?nico de pull-out. Os resultados mostraram que no est?gio inicial da cicatriza??o, o horm?nio do cres-cimento recombinante humano favoreceu a neoforma??o ?ssea, independente do tipo de superf?cie. Por?m, no est?gio tardio, a nanotexturiza??o, sem a presen?a do horm?nio, exerceu uma influ?ncia positiva na neoforma??o ?ssea, quando compa-rada ao seu emprego com o horm?nio. Neste est?gio, apenas a superf?cie de plas-ma-spray (PSA) foi favorecida pelo horm?nio do crescimento
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/3219 |
| Date | 30 August 2012 |
| Creators | Veleda, Paula Pr? |
| Contributors | H?bler, Roberto |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Engenharia e Tecnologia de Materiais, PUCRS, BR, Faculdade de Engenharia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | -7432719344215120122, 500, 600, -655770572761439785 |
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