mRNA Cap Methylation in Pluripotency and Differentiation

Description

Yes / The mRNA cap stabilizes transcripts and
recruits processing and translation
factors. Grasso et al. report that the
mRNA cap methyltransferase RNMTRAM
is highly expressed in embryonic
stem cells and is important for
pluripotency-associated gene
expression. Repression of RAM occurs
during neural differentiation and is
important for expression of neuralassociated
genes. / Wellcome Trust

Links & Downloads

1. Grasso L, Suska O, Davidson L et al (2016) mRNA Cap Methylation in Pluripotency and Differentiation. Cell Reports. 16: 1-14.
2. http://hdl.handle.net/10454/8769
3. https://doi.org/10.1016/j.celrep.2016.06.089

Tags

mRNA cap

methyltransferase

RNMT-RAM

Gene expression

Neural-associated genes

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/8769
Date	02 August 2016
Creators	Grasso, L., Suska, O., Davidson, L., Gonatopolous-Pournatzis, T., Williamson, Ritchie, Wasmus, L., Wiedlich, S., Peggie, M., Stavridis, M.P., Cowling, V.H.
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, Published version
Rights	(c) 2016 The Authors. This is an Open Access article under the CC-BY license (http://creativecommons.org/licenses/by/4.0/ ), CC-BY