Two polymorphisms in the promoter region of macrophage migration inhibitory factor
(MIF)—rs755622 and rs5844572—exhibit prognostic relevance in inflammatory diseases. The aim
of this study was to investigate a correlation between these MIF promoter polymorphisms and the
severity of hepatitis C virus (HCV)-induced liver fibrosis. Our analysis included two independent
patient cohorts with HCV-induced liver fibrosis (504 and 443 patients, respectively). The genotype
of the single nucleotide polymorphism (SNP) -173 G/C and the repeat number of the microsatellite
polymorphism -794 CATT5–8 were determined in DNA samples and correlated with fibrosis severity.
In the first cohort, homozygous carriers of the C allele in the rs755622 had lower fibrosis stages
compared to heterozygous carriers or wild types (1.25 vs. 2.0 vs. 2.0; p = 0.03). Additionally,
7 microsatellite repeats were associated with lower fibrosis stages (<F2) (p = 0.04). Comparable
tendencies were observed in the second independent cohort, where fibrosis was assessed using
transient elastography. However, once cirrhosis had been established, the C/C genotype and higher
microsatellite repeats correlated with impaired liver function and a higher prevalence of hepatocellular
carcinoma. Our study demonstrates that specific MIF polymorphisms are associated with disease
severity and complications of HCV-induced fibrosis in a stage- and context-dependent manner.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:89431 |
| Date | 31 January 2024 |
| Creators | Wirtz, Theresa Hildegard, Fischer, Petra, Backhaus, Christina, Bergmann, Irina, Brandt, Elisa Fabiana, Heinrichs, Daniel, Koenen, Maria Teresa, Schneider, Kai Markus, Eggermann, Thomas, Kurth, Ingo, Stoppe, Christian, Bernhagen, Jürgen, Bruns, Tony, Fischer, Janett, Berg, Thomas, Trautwein, Christian, Berres, Marie-Luise |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 3753 |
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