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Previous issue date: 2008-02-26 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / Ameloblastoma and adenomatoid odontogenic tumor are odontogenic tumors arising from the odontogenic epithelium with distinct clinical behavior. In attempt to comprehend the interaction between the odontogenic tumor cells and the
extracellular matrix, the present work evaluated and compared the immunohistochemical expression of the matrix metalloproteinases-1 (MMP-1), -2 (MMP-2) and -9 (MMP-9) in 20 cases of ameloblastoma and 10 adenomatoid
odontogenic tumor. MMP-1 exhibited exuberant expression in the parenchyma and in the stroma of both studied tumors, while the MMP-2 showed varied expression with
about of 80% and 60% of the neoplastic cells exhibiting positivity in the ameloblastoma and adenomatoid odontogenic tumor, respectively. With relation to the MMP-2 expression by the mesenchymal cells, it was observed that 65% of the
ameloblastoma and 80% of the adenomatoid odontogenic tumor were positive. The immunoreactivity of MMP-9 was detected in all studied cases, although its expression
had occurred predominantely in less than 50% of the parenchyma cells of the ameloblastoma, while in about of 60% of the adenomatoid odontogenic tumor more than 50% of cells were positive. The mesenchymal cells were positive to MMP-9 in 65% of the ameloblastoma and in 80% of the adenomatoid odontogenic tumor, respectively. Statistically significant difference was observed to the MMP-1
expression with relation to MMP-2 and MMP-9 in the ameloblastoma (p < 0.001). It was not possible to perform statistical analysis to the cases of adenomatoid
odontogenic tumor, however there was a tendency toward a differential expression of the MMP-1 with relation to other studied MMPs. These results suggest that MMP-1, -
2 and -9 are implicated in the growth and progression of both tumors analyzed as well as the more pronounced participation of the stroma in the ameloblastoma could together to be related to the higher clinical aggressiveness / O ameloblastoma e o tumor odontog?nico adenomat?ide s?o tumores odontog?nicos derivados do epit?lio odontog?nico que possuem comportamentos distintos. Na tentativa de compreender a intera??o existente entre as c?lulas
tumorais e a matriz extracelular, o presente trabalho teve como objetivo avaliar e comparar a express?o das metaloproteinases-1 (MMP-1), -2 (MMP-2) e -9 (MMP-9),
atrav?s da t?cnica imuno-histoqu?mica em 20 casos de ameloblastoma e 10 de tumor odontog?nico adenomat?ide. A MMP-1 teve uma marca??o predominante nos dois tumores, sendo observada tanto no par?nquima como no estroma de todos os tumores estudados. Para a MMP-2, observou-se uma express?o variada, sendo 80% e 60% das c?lulas tumorais imunorreativas nos ameloblastomas e tumores odontog?nicos adenomat?ides, respectivamente. Em rela??o ?s c?lulas do
mes?nquima, 65% dos ameloblastomas e 80% tumores odontog?nicos adenomat?ides exibiram positividade. Verificou-se imunoexpress?o para a MMP-9 nas c?lulas parenquimatosas e estromais em todos os casos, sendo que nos ameloblastomas, houve o predom?nio de menos de 50% das c?lulas imunomarcadas; enquanto que em 60% dos tumores odontog?nicos adenomat?ides mais de 50% das c?lulas apresentaram positividade. Observou-se diferen?a
estatisticamente significante na express?o da MMP-1 em rela??o ? MMP-2 e -9 nos ameloblastomas (p<0,001). A an?lise estat?stica n?o p?de ser aplicada para os
tumores odontog?nicos adenomat?ides, por?m verificou-se tend?ncia de maior express?o da MMP-1 em rela??o ?s outras MMPs avaliadas. Os resultados deste estudo sugerem que as MMPs-1, -2 e -9 est?o relacionadas com crescimento e
progress?o dos tumores analisados e, particularmente no ameloblastoma, sua maior agressividade pode resultar, em parte, pela participa??o tamb?m do estroma presente de forma bem mais marcante permeando o par?nquima tumoral e sendo fonte tamb?m das proteases estudadas
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/17098 |
| Date | 26 February 2008 |
| Creators | Ribeiro, Betania Fachetti |
| Contributors | CPF:28444361453, http://lattes.cnpq.br/9512014003639405, Cruz, Maria Carmen Fontoura Nogueira da, CPF:33243158320, http://lattes.cnpq.br/8702018716079552, Galv?o, H?bel Cavalcanti, CPF:41291824472, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4794937Z9, Freitas, Roseana de Almeida |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Patologia Oral, UFRN, BR, Odontologia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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