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Previous issue date: 2014-02-24 / Purpose: Increased expression of tissue factor (TF) was correlated with worse prognosis and survival in various malignant neoplasms. In urologic tumors, it was studied in prostate, bladder and kidney cancers. The present study evaluates the immunohistochemical expression of TF in human penile cancer, correlating it with prognostic factors and survival.
Materials and Methods: A total of 34 patients were treated by partial or total penectomy for penile carcinoma at our institution from January 1998 to December 2012. The immunohistochemical expression of TF was determined by a quantitative methodology in formalin-fixed paraffin-embedded tissue samples and correlated with age, clinical stage, pathologic stage, lymph node metastases, tumor grade and survival.
Results: Immunohistochemical expression of TF was observed in 26/34 (76.4%) specimens. The mean area of TF expression in the samples was 27.82 μm2 [95% CI 20.0 35.6, SD 22.4]. Mean age was significantly lower among patients with increased TF expression in comparison to those with lower TF expression [57.6 (SD 9,9) vs. 67.3 years (SD 16,4); p = 0.047). Mean postoperative follow-up was 28.3 months (from 1 to 139.6 months). There were eight deaths (23.5%), four in each group, all related to the penile cancer. In multivariate analyses, there was no statistically significant correlation between TF expression and the study variables.
Conclusions: TF was expressed in most samples of penile cancers. There was no statistically significant correlation between TF expression, prognostic factors and survival. / Embasamento: O aumento da express?o do fator tecidual (FT) foi correlacionado com pior progn?stico e sobrevida em v?rias neoplasias malignas. Em tumores urol?gicos, foi estudado na pr?stata, bexiga e rim. No presente estudo avaliamos a express?o imunoistoqu?mica do FT em esp?cimes de c?ncer de p?nis, correlacionando com fatores progn?sticos e sobrevida. Materiais e M?todos: Um total de 34 pacientes tratados com penectomia parcial ou total por c?ncer de p?nis no Hospital S?o Lucas da PUCRS no per?odo entre janeiro de 1998 a dezembro de 2012 foram inclu?dos no estudo. A express?o do FT foi determinada com metodologia quantitativa em amostras de tecido em parafina e correlacionada com idade, estadiamento cl?nico, estadiamento patol?gico, envolvimento linfonodal, grau de diferencia??o histol?gico e sobrevida. Resultados: A express?o do FT foi observada em 26 esp?cimes (76,4%). A m?dia da express?o na amostra foi de 27,8 μm2 [IC 95% 20,0 35,6, DP 22,4]. Houve diferen?a significativa em rela??o a idade entre os grupos com express?o alta e baixa [57,6 anos (DP 9,9) contra 67,3 anos (DP 16,4), p = 0,047]. O seguimento m?dio foi de 28,3 meses (intervalo de 1 a 139,6 meses). Durante o acompanhamento houve 8 ?bitos (76,5%), 4 em cada grupo, todos relacionados a neoplasia. Na an?lise multivariada, n?o houve correla??o entre a express?o do FT e as vari?veis em estudo. Conclus?es: O FT foi expresso na maioria das amostras de c?ncer de p?nis. N?o houve correla??o entre n?vel de express?o do FT, fatores progn?sticos e sobrevida.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/1773 |
| Date | 24 February 2014 |
| Creators | Fay, Carlos Eduardo Schio |
| Contributors | Carvalhal, Gustavo Franco |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Medicina e Ci?ncias da Sa?de, PUCRS, BR, Faculdade de Medicina |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 7620745074616285884, 500, 600, -8624664729441623247 |
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