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Inhibition of Escherichia coli trimethylamine-N-oxide reductase by food preservatives

Trimethylamine-N-oxide (TMA-0) reductase activity of resting cells
of Escherichia coli was inhibited by tetrasodium ethylenediaminetetraacetate
(Na₄EDTA), benzoic acid (BA), and methylparaben (MP). The 50% inhibitory
concentrations of Na₄EDTA, BA, and MP were 20.2, 1.2, and 32.4 mM,
respectively. BA at pH 6.5 or below most effectively inhibited the TMA-0
reductase.
Sorbic acid (SA), up to 0.70 mM, had no effect on TMA-0 reductase
activity, but SA inhibited the growth and subsequent TMA production in
E. coli at or above 0.35 mM. / Graduation date: 1981

Identiferoai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/27113
Date20 March 1981
CreatorsKruk, Mark W.
ContributorsLee, Jong S.
Source SetsOregon State University
Languageen_US
Detected LanguageEnglish
TypeThesis/Dissertation

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