Symbiont intestinal microbiomes contribute to host immunity, but may also contribute to autoimmune diseases. Segmented filamentous bacteria (SFB), designated Candidatus Arthromitus, are one of the key players in the gut microbiome. They have a unique cell cycle and are thought to play a role in immune establishment in infancy. This research explored the feasibility of non-human primate infants as animal models for elucidating SFB function by analyzing previously published 16S rRNA gene sequencing data with the Divisive Amplicon Denoising Algorithm 2 (DADA2) algorithm and statistical methods. Consequently, non-human primate infants as animal models for SFB investigation were seen as a potential option. However, the study also brought up questions about the species-specificity and transmission modes of SFB, thus additional research is needed.
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:uu-526710 |
| Date | January 2024 |
| Creators | Yoshida, Emiko |
| Publisher | Uppsala universitet, Institutionen för biologisk grundutbildning, Uppsala University / Science for Life Laboratory |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Student thesis, info:eu-repo/semantics/bachelorThesis, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
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