This thesis presents three main contributions in the context of modeling and simulation of physiological systems. The first one is a formalization of the methodology involved in multi-formalism and multi-resolution modeling. The second one is the presentation and improvement of a modeling and simulation framework integrating a range of tools that help the definition, analysis, usage and sharing of complex mathematical models. The third contribution is the application of this modeling framework to improve diagnostic and therapeutic strategies for clinical applications involving the cardiovascular system: hypertension-based heart failure (HF) and coronary artery disease (CAD). A prospective application in cardiac resynchronization therapy (CRT) is also presented, which also includes a model of the therapy. Finally, a final application is presented for the study of the baroreflex responses in the newborn lamb. These case studies include the integration of a pulsatile heart into a global cardiovascular model that captures the short and long term regulation of the cardiovascular system with the representation of heart failure, the analysis of coronary hemodynamics and collateral circulation of patients with triple-vessel disease enduring a coronary artery bypass graft surgery, the construction of a coupled electrical and mechanical cardiac model for the optimization of atrio ventricular and intraventricular delays of a biventricular pacemaker, and a model-based estimation of sympathetic and vagal responses of premature newborn lambs.
| Identifer | oai:union.ndltd.org:CCSD/oai:tel.archives-ouvertes.fr:tel-01056825 |
| Date | 10 December 2013 |
| Creators | Ojeda Avellaneda, David |
| Publisher | Université Rennes 1 |
| Source Sets | CCSD theses-EN-ligne, France |
| Language | English |
| Detected Language | English |
| Type | PhD thesis |
Page generated in 0.0017 seconds