M.Sc. (Physiotherapy), Faculty of Health Sciences, University of the Witwatersrand, 2008. / Paediatric Human Immunodeficiency Virus (HIV) remains a significant challenge to
children and caregivers in South Africa. Although the availability of antiretroviral (ARV)
therapy has improved, it is not yet universally accessible. Rates of transmission from
mother to child thus remain high and the virus widely uncontrolled.
One aspect affecting children infected with HIV is that of muscle strength. For children
weakness has been inferred by way of developmental studies in young children infected
with HIV. Impaired performance in activities such as standing, walking, stair-climbing
and jumping have been noted. These gross motor activities require higher muscle
outputs and strength against gravity.
This study sought to ascertain the feasibility of a full study on muscle strength in
children infected with HIV. It analysed the effect of HIV on muscle strength, height and
weight of those children receiving and not receiving highly active antiretroviral therapy
(HAART). Children were recruited from Harriet Shezi Children’s HIV Clinic at Chris
Hani Baragwanath Hospital, Soweto, Gauteng Province, South Africa. The study
population included a group of children receiving HAART (n=16) and a group of children
not receiving HAART (n=16). A once off test of muscle strength was administered to
each child using a hand-held dynamometer. A demographic questionnaire and the
Household Economic and Social Status Index (HESSI) were administered to their
primary caregiver.
Results showed the sample population to be of low socio-economic status (average
score=54%) and the children to be underweight and short for their age (p<0.001). The
CD4 count of the group on HAART was significantly higher than the group not receiving
HAART (p<0.05). The group not receiving HAART was significantly stronger than the
HAART group (p<0.05). Length of time having received HAART and muscle strength
showed no significant correlation (p=0.647). No significant correlation was shown
between CD4 count and muscle strength in the group receiving HAART (p>0.1). A
significant negative correlation was shown between CD4 count and muscle strength in
the group not receiving HAART (p<0.05). As statistically significant normative muscle
strength data for children not infected with HIV in this age group fails to exist, the study
was unable to ascertain a quantitative measure of weakness in these children.
Comparison of those values available, however, showed normative values to be double
that of children who participated in the study.
The implications of these findings are that as one observes this group of children’s CD4
count drop, so too does their muscle strength. HAART, once initiated, stems the
decrease in muscle strength over a period of time but does not reverse it. Furthermore,
children and caregivers who participated in this study were faced with the adversities of
poor socioeconomic status, limited access to medication and ARV treatment and
inadequate nutritional intake, most of which were largely beyond their immediate
control.
This pilot study has indicated the feasibility and importance of a full study to investigate
the muscle strength of children infected with HIV. Further research is needed to
establish the impact of earlier administration of HAART on muscle strength. The effect
of exercise on the muscle strength of children who are infected with HIV has yet to be
documented. The implication of these factors on gross motor development in children infected with HIV has yet to be investigated.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/7353 |
| Date | 14 October 2009 |
| Creators | Zeijlstra, Carolyn Ruth Michelle |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | application/pdf, application/pdf |
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