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Facile Synthesis of Anticancer Drug NCX 4040 in Mild Conditions

A simple method is reported to synthesize an anticancer drug, NCX 4040, conveniently in mild conditions using silicon chemistry. A starting material, 4-hydroxybenzyl alcohol, was silylated selectively first to give t-butyldimethylsilyl 4-hydroxybenzyl ether, which was then converted to NCX 4040 by esterification, desilylation, hydrochlorination and nitration.

Identiferoai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-18950
Date01 October 2008
CreatorsXiao, Mei, Yang, Hongsong, Klein, Suzane M., Muenyi, Christian M., Stone, William L., Jiang, Yu L.
PublisherDigital Commons @ East Tennessee State University
Source SetsEast Tennessee State University
Detected LanguageEnglish
Typetext
SourceETSU Faculty Works

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