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PGC-1s in the Spotlight with Parkinson’s Disease

Parkinson’s disease is one of the most common neurodegenerative disorders worldwide,
characterized by a progressive loss of dopaminergic neurons mainly localized in the substantia nigra
pars compacta. In recent years, the detailed analyses of both genetic and idiopathic forms of the disease
have led to a better understanding of the molecular and cellular pathways involved in PD, pointing
to the centrality of mitochondrial dysfunctions in the pathogenic process. Failure of mitochondrial
quality control is now considered a hallmark of the disease. The peroxisome proliferator-activated
receptor gamma coactivator 1 (PGC-1) family acts as a master regulator of mitochondrial biogenesis.
Therefore, keeping PGC-1 level in a proper range is fundamental to guarantee functional neurons.
Here we review the major findings that tightly bond PD and PGC-1s, raising important points that
might lead to future investigations.

Identiferoai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:88721
Date19 December 2023
CreatorsPiccinin, Elena, Sardanelli, Anna Maria, Seibel, Peter, Moschetta, Antonio, Cocco, Tiziana, Villani, Gaetano
PublisherMDPI
Source SetsHochschulschriftenserver (HSSS) der SLUB Dresden
LanguageEnglish
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text
Rightsinfo:eu-repo/semantics/openAccess
Relation3487, 10.3390/ijms22073487

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