Objectives: The aim of the retrospective study was to describe the brain biopsy procedure using a new
frameless optical neuronavigation system and to report diagnostic yield and complications associated
with the procedure.
Materials and Methods: The medical records for all dogs with forebrain lesions that underwent brain
biopsy with a frameless optical neuronavigation system in a single referral hospital between 2013 and
2020 were retrospectively analysed. Following data were collected: signalment, neurological signs,
diagnostic findings, number of brain biopsy samples, sampled region, complications, duration of hospitalisation,
whether the samples were diagnostic and histopathological diagnoses. The device consists
of a computer workstation with navigation software, an infrared camera, patient tracker and reflective
instruments. The biopsy needle was equipped with reflective spheres, so the surgeon could see the
position of the needle during sampling the intracranial lesion free handed through a mini-burr hole.
Results: Ten dogs were included. Absolute diagnostic yield based on specific histopathological diagnosis
was 73.9%. Three dogs had immune-mediated necrotizing encephalitis, two dogs showed a
necrotizing leukoencephalitis and two dogs a meningoencephalitis of unknown origin. In two dogs,
the brain specimen showed unspecific changes. In one dog, the samples were non-diagnostic. Seven
dogs showed no neurological deterioration, one dog mild temporary ataxia and two dogs died within
36 hours post brain biopsy.
Clinical Significance: In these 10 dogs, the frameless optical neuronavigation system employed was useful
to gain diagnostic brain biopsy samples. Considering the mortality rate observed, further studies
are needed to confirm the safety of this procedure and prove its actual clinical effectiveness.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:88874 |
| Date | 05 January 2024 |
| Creators | Gutmann, S., Tästensen, C., Böttcher, I.C., Dietzel, J., Loderstedt, S., Kohl, S., Matiasek, K., Flegel, T. |
| Publisher | Wiley |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
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