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Epigenetic regulation of stroke recovery : changes in DNA methylation and micro-RNA regulation following stroke and EGF/EPO neurogenesis therapy

Stroke is one of the most common, and damaging, neurological afflictions.

Stroke causes widespread and variable chronic effects, due to the limited regenerative

ability of the adult brain. Altered gene expression induces neuronal changes

necessary for plasticity-dependent recovery, effects which can be enhanced by growth

hormone-based pharmaceuticals. These processes are driven by alterations in the

informational capacity of the genome – changes driven by epigenetic regulators.

Following experimental strokes, and treatment with EGF and EPO, this study shows

that two epigenetic regulatory mechanisms, DNA methylation and microRNA

regulation, are significantly altered, both in treated and untreated animals.

Specifically, treatment induces a net global suppression of miRNA activity, which

appears to modify the physical behaviour of neurons in domains ranging from

plasticity and memory formation, growth and replication, and potentially even to

neurological disease signalling. The confirmation of epigenetic alterations following

a stroke indicates a future role for epigenetic neuro-pharmacology in stroke

management. / x, [99] leaves : ill. (some col.) ; 29 cm

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:ALU.w.uleth.ca/dspace#10133/2570
Date January 2010
CreatorsLowings, Michael D, University of Lethbridge. Faculty of Arts and Science
ContributorsKovalchuk, Olga
PublisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010, Arts and Science, Department of Biological Sciences
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
Languageen_US
Detected LanguageEnglish
TypeThesis
RelationThesis (University of Lethbridge. Faculty of Arts and Science)

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