Indiana University-Purdue University Indianapolis (IUPUI) / Adaptive Optics Optical Coherence Tomography (AO-OCT) is a high-speed, high-resolution ophthalmic imaging technique offering detailed 3D analysis of retina structure in vivo. However, AO-OCT volume images are sensitive to involuntary eye movements that occur even during steady fixation and include tremor, drifts, and micro-saccades. To correct eye motion artifacts within a volume and to stabilize a sequence of volumes acquired of the same retina area, we propose a stripe-wise 3D image registration algorithm with phase correlation. In addition, using several ideas such as coarse-to-fine approach, spike noise filtering, pre-computation caching, and parallel processing on a GPU, our approach can register a volume of size 512 x 512 x 512 in less than 6 seconds, which is a 33x speedup as compared to an equivalent CPU version in MATLAB. Moreover, our 3D registration approach is reliable even in the presence of large motions (micro-saccades) that distort the volumes. Such motion was an obstacle for a previous en face approach based on 2D projected images. The thesis also investigates GPU implementations for 3D phase correlation and 2D normalized cross-correlation, which could be useful for other image processing algorithms.
| Identifer | oai:union.ndltd.org:IUPUI/oai:scholarworks.iupui.edu:1805/10904 |
| Date | 08 July 2016 |
| Creators | Do, Nhan Hieu |
| Contributors | Lee, John Jaehwan, Miller, Donald T., King, Brian, Salama, Paul |
| Source Sets | Indiana University-Purdue University Indianapolis |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
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