Mantle cell lymphoma (MCL) is a non-Hodgkin B-cell lymphoma with very bad prognosis. The genetic hallmark of MCL, is the translocation t(11;14)(q13;q32) which leads to overexpression of cyclin D1, a D-type cyclin that is not usually expressed at high levels in normal B lymphocytes. Previous studies indicate that cannabinoid receptors are expressed in lymphoma and have shown that lymphoma cell death is induced as a result of exposure to cannabinoids (ligands). The aim of this diploma work was to combined cytostatics with the cannabinoid receptor ligand R (+)-Methanandmide (R-MA). Our data suggest that combination treatment with cytostatics and R-MA induces synergistic effects in most cases.
Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:mdh-4876 |
Creators | Thirugnanam, Vasanthakumar |
Publisher | Mälardalens högskola, Mälardalens högskola, Akademin för hälsa, vård och välfärd, Mälardalens högskola, Akademin för hållbar samhälls- och teknikutveckling |
Source Sets | DiVA Archive at Upsalla University |
Language | English |
Detected Language | English |
Type | Student thesis, info:eu-repo/semantics/bachelorThesis, text |
Format | application/pdf, application/pdf |
Rights | info:eu-repo/semantics/openAccess, info:eu-repo/semantics/openAccess |
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