Obesity is a growing health problem characterized by a variety of related complications like fatty liver disease, Type 2 diabetes and cardiovascular diseases. One of the major organs relevant for obesity is the adipose tissue (AT) and in the last decades it has been shown that AT is an endocrine organ located in different sites of the body. The AT is mainly distributed in two depots, the subcutaneous adipose tissue (ScAT) and visceral adipose tissue (VAT). It is well acknowledged that fat stored prominently in VAT makes subjects more prone for metabolic complications. It is also known that obesity as well as fat distribution are controlled by genetic factors including single nucleotide polymorphisms, deletions or insertions of nucleotides or sequences; but also the altered mRNA expression or epigenetic modifications like DNA methylation play a role. There is clear evidence that the majority of obesity cases have a polygenic character. This thesis aims to identify and characterize novel candidate ( HIF3A, REPIN1, IRX3/5 and KLF13) genes to gain further insights into different types of obesity and into causes and consequences of adverse FD, including related comorbidities.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:37375 |
| Date | 14 January 2020 |
| Creators | Herold (geb. Krüger), Jacqueline |
| Contributors | Universität Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/acceptedVersion, doc-type:doctoralThesis, info:eu-repo/semantics/doctoralThesis, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 10.1038/srep27969, 10.1038/s41366-018-0123-0 |
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