Protein energy malnutrition (PEM) is a range of pathological conditions arising from coincident deficiency of proteins and calories in varying proportions occurring mostly in infants and young children. According to Welcome classification, PEM is classified into mild form (underweight) and severe form (marasmus, kwashiorkor or marasmic kwashiorkor) (Wellcome, 1970). The assessment of nutritional condition may be done through clinical examination, anthropometric measures or biochemical tests. The insulin-like growth factors (IGFS), are defined as polypeptide growth factors secreted by the liver and other tissues in response to stimulation by growth hormone (GH) (Guyton, 1996). In humans, there are two main forms of IGFS: Irsulin-like growth foctor-1 (IGF-1) and insulin-like growth foctor-11 (IGF-11). The most important of these is IGF-1, its synthesis is GH dependent, and its plasma levels are very sensitive to changes in GH availability (Berne et al, 1998). The IGFS circulate in plasma in complex with a family of binding proteins that extend the serum half-life of the IGF peptides, transport the IGFS to target cells and modulate the interaction of the IGFS with surface membrane receptors (Reiter and Rosenfeld, 1998). There are six IGF - binding proteins (IGFBPS) designated IGFBP-1 to IGFBP-6. They are designated on the basis of their amino acid sequence (Berne et al, 1998). IGFBP-1 is generating much interest, because it possesses properties that are a typical for a classical binding protein. It is an important modulator of IGF activities (Martina et al, 1997). IGFBP-3 is the major IGFBP in the circulation (Boisclair et al, 2001). The prealbumin is a protein synthesized by the liver. It plays an important role in the plasma transport of vitamin A, and also involved in the transport of thyroid hormones (Silverman and Christenson, 1994) The aminoterminal peptide of procollagen, are removed during processing of collagen and released into the circulation. The level of procollagen peptides may provide a clinically useful index of growth (Raisz et al., 1998). -Aim of work : The aim of work is to evaluate serum levels of IGF-1 , IGFBP-1 , IGFBP-3 , prealbumin and aminoterminal propeptide of type 1 procollagen in malnourished children and demonstrate the effect of malnutrition on these parameters.
| Identifer | oai:union.ndltd.org:TDX_UAB/oai:www.tdx.cat:10803/4609 |
| Date | 15 November 2004 |
| Creators | Alatrouni, Almahdi Mohamed |
| Contributors | Carrascosa, Antonio, 1949-, Universitat Autònoma de Barcelona. Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva |
| Publisher | Universitat Autònoma de Barcelona |
| Source Sets | Universitat Autònoma de Barcelona |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/doctoralThesis, info:eu-repo/semantics/publishedVersion |
| Format | application/pdf |
| Source | TDX (Tesis Doctorals en Xarxa) |
| Rights | ADVERTIMENT. L'accés als continguts d'aquesta tesi doctoral i la seva utilització ha de respectar els drets de la persona autora. Pot ser utilitzada per a consulta o estudi personal, així com en activitats o materials d'investigació i docència en els termes establerts a l'art. 32 del Text Refós de la Llei de Propietat Intel·lectual (RDL 1/1996). Per altres utilitzacions es requereix l'autorització prèvia i expressa de la persona autora. En qualsevol cas, en la utilització dels seus continguts caldrà indicar de forma clara el nom i cognoms de la persona autora i el títol de la tesi doctoral. No s'autoritza la seva reproducció o altres formes d'explotació efectuades amb finalitats de lucre ni la seva comunicació pública des d'un lloc aliè al servei TDX. Tampoc s'autoritza la presentació del seu contingut en una finestra o marc aliè a TDX (framing). Aquesta reserva de drets afecta tant als continguts de la tesi com als seus resums i índexs., info:eu-repo/semantics/openAccess |
Page generated in 0.002 seconds