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Optogenetics and Computer Vision for C. elegans Neuroscience and Other Biophysical Applications

This work presents optogenetics and real-time computer vision techniques to non-invasively manipulate and monitor neural activity with high spatiotemporal resolution in awake behaving Caenorhabditis elegans. These methods were employed to dissect the nematode's mechanosensory and motor circuits and to elucidate the neural control of wave propagation during forward locomotion. Additionally, similar computer vision methods were used to automatically detect and decode fluorescing DNA origami nanobarcodes, a new class of fluorescent reporter constructs.

Identiferoai:union.ndltd.org:harvard.edu/oai:dash.harvard.edu:1/9276708
Date19 July 2012
CreatorsLeifer, Andrew
ContributorsHogle, James M.
PublisherHarvard University
Source SetsHarvard University
Languageen_US
Detected LanguageEnglish
TypeThesis or Dissertation
Rightsopen

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