Prior research has suggested that life style factors, such as diet and physical activity, influence
prostate cancer (PCa) progression. Metformin intake has been shown to be associated with
decreased cancer risk in type II diabetic patients. We hypothesize that a low carbohydrate diet,
prolonged aerobic exercise and metformin treatment can all independently slow prostate tumor
development and a combination regimen will have an additive benefit. We used LNCaP
xenografts to test this hypothesis. Results revealed that a diet low in carbohydrate reduced food
consumption and a combination with exercise significantly reduced animal body weights. Ten
weeks of metformin did not significantly alter tumor growth rate compared to control animals.
Ten weeks of exercise significantly inhibited tumor growth. Out results suggest that dietary
carbohydrate alteration or the administration of metformin alone cannot significantly influence
prostate tumor progression. A suitable sustained exercise regimen may offer a more protective
effect against PCa progression.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OTU.1807/44021 |
| Date | 18 March 2014 |
| Creators | Ge, Xiangfeng |
| Contributors | Venkateswaran, Vasundara |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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