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Paper Spray - Mass Spectrometry: Investigation of Sampling Devices for Illicit Drug Detection and Quantification

Different sampling devices for paper spray - mass spectrometry (PS - MS) were investigated to improve the assay’s simplicity and sensitivity over traditional approaches. In the first one, pressure-sensitive adhesive paper was used as both sampling tool to collect drug residues on surfaces and paper substrate in PS - MS analysis. This method showed a significant improvement in drug collection on surfaces leading to low nano-gram level detection limits. Other sampling device being investigated was snap-in solid-phase extraction column, which demonstrated the ability to detect trace amounts of drugs in plasma while allowed easy transportation and the use of PS - MS automated system.

  1. 10.25394/pgs.15046341.v1
Identiferoai:union.ndltd.org:purdue.edu/oai:figshare.com:article/15046341
Date06 August 2021
CreatorsChau Bao Nguyen (11178123)
Source SetsPurdue University
Detected LanguageEnglish
TypeText, Thesis
RightsCC BY 4.0
Relationhttps://figshare.com/articles/thesis/Paper_Spray_-_Mass_Spectrometry_Investigation_of_Sampling_Devices_for_Illicit_Drug_Detection_and_Quantification/15046341

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