Yes / The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph. / This article is part of themed collection: Pharmaceutical Solids.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/8921 |
| Date | 05 August 2016 |
| Creators | Telford, Richard, Seaton, Colin C., Clout, A., Buanz, A.B.M., Gaisford, S., Williams, G.R., Prior, T.J., Okoye, C.H., Munshi, Tasnim, Scowen, Ian J. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Published version |
| Rights | (c) 2016 The Authors. This is an Open Access article licensed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by-nc/3.0/), CC-BY-NC |
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