Benzylpenicillin was found to migrate irreversibly into human erythrocytes. No detectable amounts of penicillin bind to the erythrocyte membrane. After migration into the cell, benzylpenicillin is hydrolyzed into benzylpenicilloic acid, which can not migrate out of the cell. DNDS did not affect the appearance of benzylpenicilloic acid in the erythrocyte, therefore showing that: 1) benzylpenicillin does not hydrolyze to benzylpenicilloic acid in the incubation mixture then migrate to the cell, 2) benzylpenicillin migrates into the erythrocyte and is hydrolyzed to benzylpenicilloic acid. Benzylpenicilloic acid does not migrate into erythrocytes.Ball State UniversityMuncie, IN 47306
Identifer | oai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:handle/182523 |
Date | 03 June 2011 |
Creators | Wihebrink, W. Scott |
Contributors | Wihebrink, W. Scott. RCHDCHDX compounds as stereochemical probes., Wagner, Eugene S. |
Source Sets | Ball State University |
Detected Language | English |
Format | x, 79 leaves : ill. ; 28 cm. |
Source | Virtual Press |
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