Phospholipids (PL) are converted into lipid biomarkers by the action of phospholipases
and reactive oxygen species (ROS), which are activated or released under certain
physiological and pathophysiological conditions. Therefore, the in vivo concentration
of such lipid biomarkers [e.g., lysophospholipids (LPLs)] is altered in humans and
animals under different conditions such as inflammation, stress, medication, and
nutrition. LPLs are particularly interesting because they are known to possess proand
anti-inflammatory properties and may be generated by two different pathways:
either by the influence of phospholipase A2 or by different reactive oxygen species
that are generated in significant amounts under inflammatory conditions. Both lead to
the cleavage of unsaturated acyl residues. This review provides a short summary of
the mechanisms by which lipid biomarkers are generated under in vitro and in vivo
conditions. The focus will be on lysophosphatidylcholine (LPC) because usually, this is
the LPL species which occurs in the highest concentration and is, thus, easily detectable
by chromatographic and spectroscopic methods. Finally, the effects of lipid biomarkers
as signaling molecules and their roles in different human and animal pathologies such
as infertility, cancer, atherosclerosis, and aging will be shortly discussed.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:84422 |
| Date | 30 March 2023 |
| Creators | Engel, Kathrin M., Schiller, Jürgen, Galuska, Christina E., Fuchs, Beate |
| Publisher | Frontiers Research Foundation |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1664-042X, 732319 |
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