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Mxr1p is a Global Regulator of Multiple Metabolic Pathways in the Methylotrophic Yeast Pichia Pastoris

The present study is aimed at examining the ability of Pichia pastoris to utilize acetate and amino acids as the sole sources of carbon. We demonstrate that the zinc finger transcription factor Mxr1p, which is a positive regulator of methanol metabolism, is also required for the growth of P. pastoris in media containing acetate or amino acids as the sole source of carbon. We have identified the target genes of Mxr1p in cells cultured in media containing acetate or amino acids as the sole carbon source. We conclude that Mxr1p is a global regulator of multiple metabolic pathways in P. pastoris.

Identiferoai:union.ndltd.org:IISc/oai:etd.ncsi.iisc.ernet.in:2005/3212
Date January 2016
CreatorsSahu, Umakant
ContributorsRangarajan, P N
Source SetsIndia Institute of Science
Languageen_US
Detected LanguageEnglish
TypeThesis
RelationG28356

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