Seven experiments were carried out to investigate the
involvement of carbohydrate and lipid metabolism on the
incidence of Sudden Death Syndrome (SDS) in broiler
chickens.
Hepatic arachidonate level decreased after 1 h postmortem.
The decreased level of hepatic arachidonate
previously observed in SDS birds was, therefore, associated
with the post-mortem aging.
Broiler chickens fed diets high in glucose monohydrate
(cerelose) were more susceptible to SDS mortality than
broilers fed diets high in corn starch or corn-soy. Feeding
broilers a high cerelose diet increased the levels of plasma
calcium, total protein, triacylglycerol, and uric acid
compared to broilers fed corn starch diet. Broilers fed
cerelose diet also showed the higher incidence of leg
abnormality than broilers fed corn starch or corn-soy diets.
Daily intraperitoneal injection with 0.25 ml of L(+)
lactic acid solution (100 mg lactic acid/ml) to broilers
over a 7-d period failed to reproduce the SDS incidence,
whereas intravenous injection of 40% lactic acid solution
(200 mg lactic acid/kg body weight) resulted in 100%
incidence of SDS-type mortality. No SDS-type mortality was
observed with the intravenous injection of 40% sodium
lactate solution (200 mg sodium lactate/kg body weight).
Disturbance of physiological acid-base balance might be a
factor in the SDS-type mortality.
Suboptimal thiamin level in broilers fed cerelose diets
was observed. Thiamin supplementation to cerelose diet
improved the thiamin status of the broilers. Mortality due
to SDS was decreased when thiamin hydrochloride was
supplemented to cerelose diet at the level of 0.6 and 2.8 mg
thiamin hydrochloride/kg diet, respectively. Thiamin
supplementation, however, did not change the liver pyruvate
dehydrogenase activity and the proportion of pyruvate
dehydrogenase in the active form.
Disturbance of acid-base balance was postulated to be
associated with the incidence of SDS. Other genetic,
nutritional, and environmental factors are likely to modify
the incidence by affecting the acid-base status of the
chicken. / Graduation date: 1993
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/35777 |
| Date | 29 October 1992 |
| Creators | Attamangkune, Seksom |
| Contributors | Nakaue, Harry S. |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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