Within this review, sex-specific differences in alveolar epithelial functions are discussed
with special focus on preterm infants and the respiratory disorders associated with premature birth.
First, a short overview about fetal lung development, the challenges the lung faces during perinatal
lung transition to air breathing and respiratory distress in preterm infants is given. Next, clinical
observations concerning sex-specific differences in pulmonary morbidity of human preterm infants
are noted. The second part discusses potential sex-specific causes of pulmonary complications,
including pulmonary steroid receptors and local lung steroid metabolism. With regard to pulmonary
steroid metabolism, it is important to highlight which steroidogenic enzymes are expressed at which
stage during fetal lung development. Thereafter, we review the knowledge concerning sex-specific
aspects of lung growth and maturation. Special focus is given to alveolar epithelial Na+
transport as
a driver of perinatal lung transition and the sex differences that were noted in this process.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:85995 |
| Date | 13 June 2023 |
| Creators | Laube, Mandy, Thome, Ulrich H. |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 437 |
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