The inevitable aging process can be partially attributed to the accumulation of
oxidative damage that results from the action of free radicals. Methionine sulfoxide
reductases (Msr) are a class of enzymes that repair oxidized methionine residues. The
two known forms of Msr are MsrA and MsrB which reduce the R- and S- enantiomers of
methionine sulfoxide, respectively. Our lab has created the first genetic animal model
that is fully deficient for any Msr activity. Previously our lab showed that these animals
exhibit a 20 hour delay in development of the third instar larvae (unpublished data). My
studies have further shown that the prolonged third-instar stage is due to a reduced
growth rate associated with slower food intake and a markedly slower motility. These
Msr-deficient animals also exhibit decreased egg-laying that can be attributed to a lack of
female receptivity to mating. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2016. / FAU Electronic Theses and Dissertations Collection
| Identifer | oai:union.ndltd.org:fau.edu/oai:fau.digital.flvc.org:fau_33956 |
| Contributors | Singkornrat, Diana (author), Binninger, David (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Science, Department of Biological Sciences |
| Publisher | Florida Atlantic University |
| Source Sets | Florida Atlantic University |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation, Text |
| Format | 73 p., application/pdf |
| Rights | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder., http://rightsstatements.org/vocab/InC/1.0/ |
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