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Previous issue date: 2017-06-09 / O aumento da expectativa de vida tem proporcionado a mulheres em todo o mundo viver cerca de metade de suas vidas adultas ap?s a menopausa, com defici?ncia de estr?genos. A priva??o hormonal evidenciada a partir desse per?odo de vida traz consigo um grande n?mero de consequ?ncias, incluindo d?ficit cognitivo, mudan?as nos estados de humor, incluindo depress?o e ansiedade, redu??o de qualidade do sono e sintomas caracter?sticos tais como ondas de calor, sudorese noturna, entre outros. O d?ficit cognitivo pode apresentar rela??o com os demais sintomas durante esse per?odo da vida. O objetivo desse estudo foi avaliar o desempenho cognitivo de mulheres perimenop?usicas em fun??o de transtornos de humor, comorbidades, sintomatologia climat?rica e ovariectomia cir?rgica. Sessenta e nove mulheres foram recrutadas na Maternidade Escola Janu?rio Cicco, Natal-RN. O desempenho cognitivo foi avaliado utilizando testes cognitivos para mem?ria verbal epis?dica, e fun??o executiva, incluindo mem?ria operacional, al?m de question?rio para queixas de mem?ria. Foram tamb?m investigados os transtornos de humor (depress?o e ansiedade) e a qualidade do sono. A presen?a de comorbidades e sintomatologia climat?rica foram obtidos atrav?s dos prontu?rios das participantes. As queixas de climat?rio foram mensuradas por meio do ?ndice de Blatt-Kupperman. Todas estas vari?veis, incluyindo a ovariectomia cir?rgica foram utilizadas como preditores do desempenho cognitivo por meio da an?lise estat?stica de modelo linear generalizado, considerando p < 0,05. Maiores sintomas de ansiedade e depress?o e qualidade de sono, foram preditores do desempenho cognitivo para fun??o executiva. Al?m disso, a sintomatologia climat?rica e os sintomas de depress?o foram preditores das queixas de mem?ria, mas as comorbidades n?o predisseram o desempenho cognitivo. A ovariectomia cir?rgica, mas n?o a perimenopausa natural, predisse o desempenho cognitivo dominu?do para mem?ria epis?dica. O hipoestrogenismo agudo vivenciado por mulheres ovariectomizadas cirurgicamente sugere uma r?pida altera??o cognitiva, provavelmente decorrente do efeito degenerativo do d?ficit hormonal. Nestes casos, a terapia de reposi??o hormonal, desde que observados os crit?rios para a sua prescri??o, possivelmente reduziria essa altera??o, como sugere a hip?tese da janela cr?tica de oportunidade. Portanto, no per?odo de transi??o perimenop?usica ocorrem altera??es fisiol?gicas pr?prias desta condi??o, al?m das repercuss?es do hipoestrogenismo sobre a cogni??o, estados de humor e qualidade do sono, de forma que abordagem integrada destes fatores pode favorecer a qualidade de vida das pacientes. / General life expectancy has increased, which has provided to women around the world live about half of their adult lives after menopause, facing estrogen deficiency. Hormone deprivation evidenced in this period of life brings with it a great number of consequences for women, including cognitive deficit, changes in mood such as depression and anxiety, reduced sleep quality, and characteristic symptoms of this period, which includes hot flashes and facial flush, among others. Hence, this research aims to assess whether mood, sleep quality, menopausal complaints and surgical ovariectomy predicted the cognitive performance in perimenopausal women. Sixry-nine women were recruited in the Climacteric Clinic at the Janu?rio Cicco Maternity-School, Natal-RN, Brazil. The assessment of cognitive performance occurred through tests of episodic memory, executive function and a questionnaire of memory complaints. Mood, sleep quality, comorbidities, menopausal complaints and surgical ovariectomy were analyzed as predictors of the cognitive performance. Comorbidities and menopausal symptoms data were collected in the participants? medical records. The menopausal complaints were measured by the Blatt-Kupperman Index. The statistical analysis was conducted using general linear model and all data analysis was considered significant when P-value was < 0.05. Higher anxiety and depression symptoms, as well as worse sleep quality, predicted executive function performance. Also, menopausal complaints and depression symptoms predicted memory complaints, but comorbidities did not predict cognitive performance. Surgical ovariectomy but not natural perimenopause predicted reduced episodic memory performance in women. The acute hypoestrogenism faced by surgically ovariectomized women indicates a fast change in cognitive performance, which may suggest the degenerative effect of hormonal absence and a preventive use of hormone therapy could possibly reduce this alteration, as supported by the critical windows hypothesis. Therefore, in the perimenopausal transition typical physiological alterations are commonly found, as well as hypoestrogenism repercussions on cognition, mood and sleep quality. Hence, an integrated approach of those factors may improve life quality for the climacteric patients. / 2018-09-08
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/24575 |
| Date | 09 June 2017 |
| Creators | Aguiar, J?lia Albuquerque |
| Contributors | 06705430478, Albuquerque, Fabiola da Silva, 64379620468, Maranh?o, Tecia Maria de Oliveira, 13049127449, Sousa, Maria Bernardete Cordeiro de |
| Publisher | PROGRAMA DE P?S-GRADUA??O EM PSICOBIOLOGIA, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | Portuguese |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/embargoedAccess |
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