The effects of feeding soy protein (SP) or SP plus isoflavones (IF) (150 and 400 mg IF/kg diet) on bone metabolism were assessed in female weanling and retired breeder (RB) rats fed low calcium (Ca) for five weeks. Young rats fed SP-based diets had significantly smaller reductions in bone mineral density (BMD) and bone mineral content (BMC) as a result of the low Ca diet compared to those fed casein-based diets. Added IFs had no further benefits. Soy protein also affected bone metabolism in both the young and RB rats as indicated by markers of bone resorption. Neither the SP nor the added IFs had any effects on BMD or BMC in the RB rats. Feeding SP to young rats resulted in beneficial changes in BMD, BMC, and biochemical markers of bone metabolism. This study indicates that SP positively affects bone metabolism and minimizes the negative effects associated with low Ca intakes in young rats.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.84029 |
| Date | January 2005 |
| Creators | Farnworth, Sara |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (School of Dietetics and Human Nutrition.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002270238, proquestno: AAIMR22721, Theses scanned by UMI/ProQuest. |
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