Thesis (Ph. D.)--Ohio State University, 2003. / Title from first page of PDF file. Document formatted into pages; contains xxiii, 249 p. : ill. Advisor: Robert W. Brueggemeier, College of Pharmacy. Includes bibliographical references (p. 234-249).

Reproduction de : Thèse de doctorat : Qualité et sécurité des aliments : Toulouse, INPT : 2007. / Titre provenant de l'écran-titre. Bibliogr. 266 réf.

Thesis--PlanA (M.S.)--University of Wisconsin--Stout, 2000. / Includes bibliographical references.

Soybean [Glycine max (L.) Merr.] seeds contain isoflavones that have positive impacts on human health. Field and greenhouse experiments were conducted in Quebec Canada to determine the effects of management and environmental factors [seeding date (late May and mid June), row spacing (20-, 40- and 60-cm), weeds (presence or absence), irrigation levels (low, moderate, and high) and genotypes (Proteina, Orford, and Golden)] and of foliar applications of elicitor compounds (i.e., LCOs, chitosan, and actinomycetes spores), on the isoflavone concentrations of mature soybean seeds, and other important seed characteristics. Our results indicated that environmental and agronomical factors have a great impact on soybean seed isoflavone concentrations of early maturity soybean cultivars. Year, seeding date, and weeds affected total and individual isoflavone concentrations, row spacing had no effect. Total isoflavone concentration was greater in 2003 than 2004. Seeding in mid June increased isoflavone concentration by 38%, compared to seeding in May. The presence of weeds increased total isoflavone concentrations by 9%. Isoflavone concentrations were significantly affected by cultivars and irrigation levels. In both of two growing seasons, Proteina had significantly greater isoflavone concentrations compared to Orford. Irrigation effects on isoflavone concentrations differed between years and cultivars. However, most responses were observed with the lower of the two irrigation levels, which increased isoflavone concentrations by as much as 60% compared to a non-irrigated control. Our results suggest that under greenhouse conditions most biotic elicitors tested increased the concentration of individual and total isoflavones in soybean seeds when compared to untreated control plants. LCOs proved to be the most effective in studies contrasting various elicitors. Response of field-grown plants was more variable than that of greenhouse-grown plants.

Note: / Recent years have witnessed a tremendous growth in the number of goldcatalyzeddevelop new gold catalytic methods to mediate carbon-carbon, carbon-oxygenand carbon-nitrogen bond forming reactions. Chapter 2 describes new annulations catalyzed by gold(I) of simple 0-hydroxyaldehydes with alkynes. This annulation efficiently generates isoflavanone-type structures, which have many possible applications in the synthesis of isoflavanone natural products. This chapter details the development and the optimization of the reaction conditions. The annulation was applied to various aldehydes and arylalkynes with good efficiency. Furthermore, it incorporated all atoms of both starting materials into the product and thus has a theoretical atom economy of 100%. Chapter 3 extends the scope of the annulations developed in Chapter 2. Indeed, 2,3-dihydro-l-tosylquinolin-3(1H)-one derivatives, aza-isoflavanones, have been efficiently synthesized via a gold-catalyzed annulation of 2-tosylaminobenzaldehyde and alkynes. The annulation was applied to various arylalkynes with good efficiency. This annulation can be used for the synthesis of a range of potentially bioactive molecules. [...] / Récemment nous avons constate une énorme croissance de l'utilisation de l'or comme nouveau catalyseur dans de nombreuses transformations chimiques sélectives. Le but de cette étude était de développer de nouvelles méthodes catalytiques en utilisant I' or pour former de nouveaux liens carbone-carbone, carbone-oxygène et carbone-azote. Dans le chapitre 2, nous décrirons la nouvelle addition catalysée par Por(I) entre des 2-hydroxyaldehydes et des alcynes. Cette addition produit des structures de type isoflavanones efficacement. Ces derniers sont impliques dans la synthèse de nombreux produits nature Is. L' addition a été appliquée efficacement diversaldéhydes et alcynes. En outre, l'addition a incorpore tous les atomes des produits de départ au produit final et a ainsi une économie d'atome théorique de 100%. Le développement et l'optimisation des conditions de réaction seront détailles dans ce chapitre.[...]

Recent years have witnessed a tremendous growth in the number of gold-catalyzed highly selective chemical transformations. The aim of this study was to develop new gold catalytic methods to mediate carbon-carbon, carbon-oxygen and carbon-nitrogen bond forming reactions. / Chapter 2 describes new annulations catalyzed by gold(I) of simple o-hydroxyaldehydes with alkynes. This annulation efficiently generates isoflavanone-type structures, which have many possible applications in the synthesis of isoflavanone natural products. This chapter details the development and the optimization of the reaction conditions. The annulation was applied to various aldehydes and arylalkynes with good efficiency. Furthermore, it incorporated all atoms of both starting materials into the product and thus has a theoretical atom economy of 100%. / Chapter 3 extends the scope of the annulations developed in Chapter 2. Indeed, 2,3-dihydro-1-tosylquinolin-3(1H)-one derivatives, aza-isoflavanones, have been efficiently synthesized via a gold-catalyzed annulation of 2-tosylaminobenzaldehyde and alkynes. The annulation was applied to various arylalkynes with good efficiency. This annulation can be used for the synthesis of a range of potentially bioactive molecules. / Chapter 4 describes applications in the total synthesis of the annulation developed in chapter 2. (+/-)-Pterocarpan and analogues have been efficiently synthesized via the annulation of salicylaldehydes and o-methoxymethoxylphenylacetylene followed by a one-pot reduction and acidic cyclization of the ketones. In addition, isoflavone derivatives have been synthesized rapidly via the annulation of salicylaldehyde and arylacetylenes followed by IBX/DMSO oxidation of the isoflavanones. / As part of our ongoing studies on metal-catalyzed atom economical reactions, the gold/silver-catalyzed addition of arenes to mono-substituted allene, generate exclusive terminal addition products are described in Chapter 5. / Finally, Appendix A explores the use of commercially available polymer-supported triphenylphosphine as a catalyst for the efficient gamma-addition of methyl 2-butynoate with various pronucleophiles. In addition, optimization studies shows no need of a co-catalyst for the reaction in the presence of a mixture of water:toluene (5:1). The polymer-supported triphenylphosphine is recoverable and can be reused efficiently. This gamma-addition is highly atom-economical and the reaction time was reduced under microwave irradiation.

Thesis (Ph. D.)--Ohio State University, 2004. / Document formatted into pages; contains 290 p. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Nov. 24.

Thesis, PlanB (M.S.)--University of Wisconsin--Stout, 2005. / Includes bibliographical references.

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