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Previous issue date: 2015-01-15 / In the last three decades, neuroimaging studies have provided significant
advances in knowledge of the human brain, especially of brain areas hitherto little
explored, such as olfaction. Many factors have been reported as able to alter the
olfactory threshold and, more recently, the clinical relevance related to changes in
this threshold has been largely addressed, principally in relation to
neurodegenerative diseases. In parallel, many industries have sought innovative
tools for assessing the impact of aromas in the population. Given the lack of
adequate national tools for these applications, the present research aimed to develop
a robust, automated and instrumented method for olfactory stimuli in neuroimaging
studies, with a man-machine interface able to control and visualize the function in a
user-friendly way. The results showed that the system was instrumented in a manner
compatible with the functional magnetic resonance imaging environment.
Furthermore, it nebulized the aromatic sample homogeneously and presented a
similar velocity and flow of the air in the three valves. Therefore, this instrument will
be able to help identify the mechanisms involved in olfactory threshold change in
different situations and may provide important clinical advances. Additionally, it can
be an auxiliary tool in business marketing strategies. / Os estudos de neuroimagem, nas ?ltimas tr?s d?cadas, proporcionaram
avan?os significativos no conhecimento do c?rebro humano, especialmente, de
?reas cerebrais at? ent?o pouco exploradas, como, o olfato. Muitos fatores t?m sido
referidos como capazes de alterar o limiar olfativo, e nos ?ltimos tempos, a
relev?ncia cl?nica relacionada ?s altera??es nesse limiar tem sido bastante
abordada, principalmente, em rela??o a doen?as neurodegenerativas. Em paralelo,
muitas ind?strias t?m buscado instrumentos inovadores para avaliar o impacto dos
aromas na popula??o. Dada a car?ncia de ferramentas nacionais adequadas para
essas aplica??es, o presente trabalho desenvolveu um sistema para est?mulo
olfativo robusto, instrumentado e automatizado para estudos de neuroimagens, com
uma interface homem-m?quina capaz de controlar e visualizar o funcionamento de
forma amig?vel. Os resultados obtidos demonstraram que o sistema desenvolvido foi
instrumentado de forma compat?vel com o ambiente de Resson?ncia Magn?tica
funcional. Al?m disso, nebulizou a amostra arom?tica de forma homog?nea. Dessa
forma, esse instrumento ser? capaz de auxiliar na identifica??o dos mecanismos
envolvidos na altera??o do limiar olfativo em diferentes situa??es, podendo
proporcionar avan?os cl?nicos importantes; al?m, de poder ser uma ferramenta
auxiliar em estrat?gias de marketing empresarial.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/3075 |
| Date | 15 January 2015 |
| Creators | Fachel, Fl?via Nathiely Silveira |
| Contributors | Santos, Marlise Ara?jo dos |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Engenharia El?trica, PUCRS, BR, Faculdade de Engenharia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 207662918905964549, 500, 600, -655770572761439785 |
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