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<p>The cosmos of noncoding RNAs (ncRNAs) has been thriving in recent years; so much so that
researchers are discovering them much faster than they can uncover their functions. The subset
of these RNAs that have been characterized have been noted to perform and regulate a plethora
of remarkably diverse and essential biological functions. This diversity in function is
accompanied by a large array of dynamic and elegantly folded 3-dimensional structures. In this
collection of work, we will journey through the discovery of the first catalytic noncoding RNAs
(ribozymes), explore a new method for identifying uniquely structured ribozymes, and detail the
design of a technique to select for highly structured RNAs with a high affinity for an RNA
binding partner. Although these topics vary widely within the field of RNA, this work strives to
showcase the integral relationship between intricate macromolecular structures with their
chemical and cellular functions.
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| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/11338631 |
| Date | 09 December 2019 |
| Creators | Samantha W Lee (8098916) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/EXPANDING_THE_RNA_WORLD_IDENTIFYING_SELECTING_AND_DESIGNING_UNIQUELY_STRUCTURED_RNAs/11338631 |
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