The ability to detect residual levels of leukemic blasts (measurable residual disease, MRD)
has already been integrated in the daily routine for treatment of patients with chronic myeloid and
acute lymphoblastic leukemia. In acute myeloid leukemia (AML), a variety of mostly retrospective
studies have shown that individuals in AML remission who tested positive for MRD at specific
time-points or had increasing MRD levels are at significantly higher risk of relapse and death
compared to MRD-negative patients. However, these studies differ with respect to the “MRD-target”,
time-point of MRD determination, material analyzed, and method applied. How this probably
very valuable MRD information in individual patients may be adapted in the daily clinical routine,
e.g., to separate patients who need more aggressive therapies from those who may be spared
additional—potentially toxic—therapies is still a work-in-progress. With the exception of MRD
assessment in acute promyelocytic leukemia (APL), the lack of randomized, prospective trials renders
MRD-based decisions and clinical implications in AML a difficult task. As of today, we still do
not have proof that early intervention in MRD-positive AML patients would improve outcomes,
although this is very likely. In this article, we review the current knowledge on non-APL AML MRD
assessment and possible clinical consequences.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:84610 |
| Date | 06 April 2023 |
| Creators | Jentzsch, Madlen, Schwind, Sebastian, Bach, Enrica, Stasik, Sebastian, Thiede, Christian, Platzbecker, Uwe |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2072-6694, 1625 |
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