Hair cortisol concentrations (HCC) have been found to be related to various common childhood diseases, like otitis media, conjunctivitis, respiratory viral infections, and moreover asthma. However, the confounding effects of age, gender, body mass index (BMI), pubertal stage (Tanner stages), socioeconomic status (SES) as well as of some hair maintenance procedures on HCC are still not well examined.
A cohort of 434 children aged between 5 and 18 years was examined for HCC between January 2012 and February 2015 in the context of the Leipzig LIFE Child study. Thereby anthropometric data, gender, BMI, SES and pubertal status were assessed. HCC was measured by liquid chromatography mass spectrometry. Hair maintenance procedures were evaluated by a questionnaire.
In the total cohort HCC levels ranged between 0,95 pg/mg and 29,86 pg/mg. In prepuberty, boys showed significantly higher HCC than girls (6.54 vs. 3.73pg/mg, p<0.05). During puberty HCC values in both genders converge. Higher BMI was significantly associated with higher HCC in both genders. In girls, HCC did not differ depending on Tanner stages. In boys, HCC was significantly higher in Tanner stage 1 than in stages 2-5. After adjusting for pubertal status, there was no relation between HCC and age in either boys or girls.
Measuring cortisol concentration in hair gives information about long term release of cortisol. We have found, that puberty, gender and BMI had a profound effect on HCC. As a result, further research should take into account the potentially confounding role of puberty, gender and BMI and may use the results of our study as a reference at determining values of HCC in healthy children.:1 Abkürzungsverzeichnis ...................................................................................... 1
2 Einleitung ........................................................................................................... 2
2.1 Problembereich und Forschungsstand ........................................................ 2
2.2 Pubertät ....................................................................................................... 6
2.2.1 Definition und hormoneller Ablauf ......................................................... 6
2.2.2 Tannerstadien und zeitlicher Ablauf ...................................................... 8
2.3 Cortisol....................................................................................................... 10
2.3.1 Bildung und Freisetzung ...................................................................... 10
2.3.2 Physiologie der Haarcortisolwerte ....................................................... 11
2.4 Die LIFE Child Studie ................................................................................ 12
2.4.1 Studiendesign und Ziele ...................................................................... 12
2.4.2 Anthropometrische Datenbestimmung bei Kindern in der LIFE Child Studie .................................................................................................. 13
2.5 Hypothesen, Frage- und Zielstellungen ..................................................... 14
3 Originalartikel ................................................................................................... 15
4 Zusammenfassung .......................................................................................... 24
5 Literatur ........................................................................................................... 28
6 Erklärung über eigenständige Abfassung der Arbeit ........................................ 32
7 Darstellung des eigenen Beitrages .................................................................. 33
8 Lebenslauf ....................................................................................................... 35
9 Danksagung..................................................................................................... 37
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:73114 |
| Date | 11 December 2020 |
| Creators | Wagner, Maximiliane |
| Contributors | Universität Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | German |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:doctoralThesis, info:eu-repo/semantics/doctoralThesis, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 10.1159/000504914 |
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