The variability of the postsynaptic response following a presynaptic action potential arises from: i) the neurotransmitter release being probabilistic and ii) channels in the postsynaptic cell involved in the response to neurotransmitter release, having stochastic properties. Spike timing dependent plasticity (STDP) is a form of plasticity that exhibits LTP or LTD depending on the precise order and timing of the firing of the synaptic cells. STDP plays a role in fundamental tasks such as learning and memory, thus understanding and characterizing the effect variability in synaptic transmission has on STDP is essential. To that end a model incorporating both forms of variability was constructed. It was shown that ion channel stochasticity increased the magnitude of maximal potentiation, increased the window of potentiation and severely reduced the post-LTP associated LTD in the STDP curves. The variability due to short term plasticity decreased the magnitude of maximal potentiation.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/31459 |
| Date | 20 December 2011 |
| Creators | Talasila, Harshit Sam |
| Contributors | Bardakjian, Berj |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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