Hyponatremia is common in preterm infants. The causes are usually related
to the inability of the premature kidneys to excrete a given water load,
excessive sodium losses, or inadequate sodium intake. Here, we present a
case of severe hyponatremia in an extreme preterm infant, associated with
the use of aminophylline. Aminophylline was administered intravenously
on day 1 for the treatment of apnea of prematurity. On day 3, the patient
developed hyponatremia which was not responsive to sodium replacement
and fluid restriction. Due to concerns of aminophylline‑induced hyponatremia,
aminophylline was discontinued on day 6, and within 48 h of discontinuation,
serum sodium normalized without the need for sodium supplementation. The
purpose of the case report is to present a rare complication associated with
aminophylline use and to shed light on potential deleterious effects associated
with drug shortages.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/625943 |
| Date | 10 1900 |
| Creators | Bader, Mohammad Y., Lopilato, Alex, Thompson, Leslie, Kylat, RanjitI |
| Contributors | University of Arizona, Department of Pediatrics |
| Publisher | Published by Wolters Kluwer - MedKnow |
| Source Sets | University of Arizona |
| Language | English |
| Detected Language | English |
| Type | Article |
| Rights | This is an open access article distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
| Relation | http://www.jcnonweb.com/text.asp?2017/6/4/259/216899 |
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