Background: Vaccination against SARS-CoV-2 significantly reduces the transmissibility
of the virus and the likelihood of a severe course of COVID-19, and is thus a critical component in
overcoming the current pandemic. The factors associated with adverse reactions after vaccination
against SARS-CoV-2 have not yet been sufficiently evaluated. Methods: We used the Disease Analyzer database (IQVIA) to identify 531,468 individuals who received a total of 908,869 SARS-CoV-2
vaccinations in 827 general practices in Germany between April and September 2021. Cox regression
models were used to analyze the frequency of vaccination-related side effects reported within 14 days
after SARS-CoV-2 vaccination, as well as subjects’ demographic characteristics and comorbidities.
Results: The total number of side effects documented was 28,287 (3.1% of all vaccinations). Pain in
the limb (24.3%), fatigue (21.0%), dizziness (17.9%), joint pain (15.7%), fever (9.5%), nausea (7.5%),
and myalgia (6.4%) were the most common side effects documented among the 12,575 vaccinations
with definite side effects. In the multivariate regression analysis, young age was associated with
much higher odds of reported side effects (OR18–30 years: 4.45, OR31–40 years: 3.50, OR41–50 years: 2.89).
In addition, pre-existing comorbidities such as dementia (OR: 1.54), somatoform disorder (OR: 1.53),
anxiety disorder (OR: 1.43), depression (OR: 1.37), chronic respiratory tract disease (OR: 1.27), hypertension (OR: 1.20), and obesity (1.14) significantly increased the odds of side effects. Finally, the male
sex was associated with increased odds of reported side effects (OR: 1.17). Conclusion: Our study,
based on a large outpatient database from Germany, identified young age, male sex, and pre-existing
comorbidities such as dementia, somatoform disorders, anxiety disorders, and depression as factors
associated with vaccine-related adverse events diagnosed in GP practices. These data could help to
identify subgroups needing particular advice and care in the context of SARS-CoV-2 vaccinations.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:85914 |
| Date | 09 June 2023 |
| Creators | Loosen, Sven H., Bohlken, Jens, Weber, Kerstin, Konrad, Marcel, Luedde, Tom, Roderburg, Christoph, Kostev, Karel |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English, German |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 566 |
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