The underlying mechanism for the origin of ultradian rhythms is not clearly understood at present. Based on a recent study from our laboratory, we have conceptualized a model for the origin of quasiperiodic ultradian rhythms in sleep-wake state. This model hypothesizes that the ultradian rhythms of sleep-wake state may be generated by a mechanism that includes the sleep-wake homeostat. The main purpose of the present study was to test the hypothesis that sleep homeostasis and sleep-wake ultradian rhythms share a common underlying mechanism. The present study has refuted that hypothesis. I conclude that: (1) the proposed model for the generation of quasiperiodic ultradian rhythms in sleep-wake state in mammals is overly simplistic in its present form, (2) the generation of ultradian rhythms in sleep-wake state probably arise from a more complex systemic interactions between the sleep-wake oscillatory network and other internal/external inputs, rather than the simple expression of sleep homeostat.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/43084 |
| Date | 04 December 2013 |
| Creators | Lim, Joonbum |
| Contributors | Stephenson, Richard |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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