Background: Serumlipid concentrations are thought to be risk factors for the development of cardiovascular disease. The present study aims to investigate the prevalence of dyslipidemia and provide sex- and age-related reference values for triglycerides, total cholesterol, LDL and HDL cholesterol as well as apolipoproteins A1 and B by using modern analytical approaches.
Materials and methods: Venous blood and anthropometric data were collected from 2571 subjects of the LIFE Child study, aged between 0.5 and 16 years. Age- and gender-related reference intervals (3rd and 97th percentiles) were established by using Cole's LMS method.
Results: Serumconcentrations of TC, LDL-C, TG and ApoBwere higher in girls than in boys. In girls TC reached peak levels two years earlier than in boys. Triglyceride levels initially declined until the school age.Until early adolescence
there was a steady increase. The LDL-C concentrations in girls and boys followed similar patterns to that of TC. Up to the age of 8 years, a continuous increase in HDL levels for both sexeswas found. Due to the strong correlation between HDL-C and ApoA1 (r=0.87) or rather between LDL-C and ApoB (r=0.93), the respective percentiles showed very similar patterns. Dyslipidemia prevalence were as follows: increased TC 7.8%, increased LDL 6.1%, increased TG 0–9 years 22.1%, increased TG 10–16 years 11.7%, and decreased HDL 8.0%.
Conclusion: Age- and sex-related trends for all parameters are similar to those of the German KIGGS study. With the exception of HDL cholesterol, the prevalence of dyslipidemias in the German LIFE Child cohort are similar to the US-American prevalence.:I Abkürzungsverzeichnis - 03 -
1 Bibliographische Beschreibung - 04 -
2 Einleitung - 05 -
2.1 Hintergrund - 05 -
2.2 Serumlipide, Apolipoproteine und Dyslipidämien - 05 -
2.3 Referenzintervalle - 08 -
2.4 Soziodemographische Faktoren - 10 -
2.5 Die LIFE-Child Studie - 12 -
2.6 Hypothesen, Frage- und Zielstellungen - 13 -
3 Publikationen - 14 -
3.1 Pediatric reference data of serum lipids and prevalence of dyslipidemia: results
from a population-based cohort in Germany - 15 -
3.2 Serum lipid levels were related to socio-demographic characteristics in a
German population-based child cohort. Serum lipid levels and social class - 25 -
4 Zusammenfassung - 33 -
5 Literaturverzeichnis - 36 -
II Anhang - 45 -
III Erklärung über die eigenständige Abfassung der Arbeit - 64 -
IV Curriculum vitae - 65 -
V Danksagung - 66 - / Aim: Socio-demographic factors affect the development and lives of children and
adolescents. We examined links between serum lipids and apolipoproteins and sociodemographic factors in the Leipzig Research Centre for Civilization Diseases Child (LIFE Child) study.
Methods: The Winkler index and the Family Affluence Scale were used to define
characteristics of the social status of 938 boys and 860 girls aged from birth to 19 years. We then used univariate and multivariate regression analyses to examine the sociodemographic impact on total cholesterol, low-density lipoprotein (LDL) cholesterol, highdensity lipoprotein (HDL), cholesterol triglycerides and apolipoproteins A1 (ApoA1) and B (ApoB).
Results: No significant influences on the Winkler index or the Family Affluence Scale were observed regarding the concentrations of serum lipids for total cholesterol or LDL cholesterol. However, and most importantly, children and adolescents with high social status and high family affluence showed significantly higher HDL cholesterol and ApoA1 levels than those with lower individual totals. A higher Winkler index was associated with significantly lower values for triglycerides and ApoB.
Conclusion: Adolescents with higher family wealth and social status showed a lower cardiovascular risk profile, as measured by the concentrations of HDL cholesterol and triglycerides as well as ApoA1 and B.:I Abkürzungsverzeichnis - 03 -
1 Bibliographische Beschreibung - 04 -
2 Einleitung - 05 -
2.1 Hintergrund - 05 -
2.2 Serumlipide, Apolipoproteine und Dyslipidämien - 05 -
2.3 Referenzintervalle - 08 -
2.4 Soziodemographische Faktoren - 10 -
2.5 Die LIFE-Child Studie - 12 -
2.6 Hypothesen, Frage- und Zielstellungen - 13 -
3 Publikationen - 14 -
3.1 Pediatric reference data of serum lipids and prevalence of dyslipidemia: results
from a population-based cohort in Germany - 15 -
3.2 Serum lipid levels were related to socio-demographic characteristics in a
German population-based child cohort. Serum lipid levels and social class - 25 -
4 Zusammenfassung - 33 -
5 Literaturverzeichnis - 36 -
II Anhang - 45 -
III Erklärung über die eigenständige Abfassung der Arbeit - 64 -
IV Curriculum vitae - 65 -
V Danksagung - 66 -
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:16133 |
| Date | 24 August 2017 |
| Creators | Dathan-Stumpf, Anne |
| Contributors | Universität Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | German |
| Detected Language | English |
| Type | doc-type:doctoralThesis, info:eu-repo/semantics/doctoralThesis, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
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