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Previous issue date: 2012-01-05 / Introduction: The leukemias are the most common malignancy in children and
adolescents. With the improvement in outcomes, there is a need to consider the
morbidity to generate the protocols used in children under treatment. Aim: To
evaluate pulmonary function in children with acute leukemia. Method: This study is
an observational cross sectional. We evaluated 34 children distributed in groups A
and B. Group A comprised 17 children with acute leukemia in the maintenance phase
of chemotherapy treatment and group B with 17 healthy students from the public in
the city of Natal / RN, matched for gender, age and height. The thoracic mobility was
evaluated by thoracic expansion in the axillary and xiphoid levels. Spirometry was
measured using a spirometer Microloop Viasys ? following the rules of the ATS and
ERS. Maximal respiratory pressures were measured with digital manometer MVD300
(Globalmed ?). The maximal inspiratory pressure (MIP) and maximal expiratory
pressure (MEP) were measured from residual volume and total lung capacity,
respectively. The data were analyzed using the SPSS 17.0 software assigning the
significance level of 5%. Descriptive analysis was expressed as mean and standard
deviation. T'student test was used to compare unpaired values found in group A with
group B values, as well as with the reference values used. To compare the
respiratory coefficients in the axillary level with the xiphoid in each group, we used
paired testing t student. Results: Group A was significantly decreased thoracic
mobility and MIP compared to group B, and MIP compared to baseline. There was no
significant difference between spirometric data from both groups and the values of
group A with the reference values Mallozi (1995). There was no significant difference
between the MIP and MEP values and lower limits of reference proposed by Borja
(2011). Conclusion: Children with acute leukemia, myeloid or lymphoid, during
maintenance phase of chemotherapy treatment have reduced thoracic mobility and
MIP. However, to date, completion of clinical treatment, the spirometric variables and
the strength of the expiratory muscles appear to remain preserved in children
between five and ten years / Introdu??o: As leucemias constituem a doen?a maligna mais frequente em crian?as
e adolescentes. Com a melhora no progn?stico, surge a necessidade de considerar
a morbidade que os protocolos utilizados geram nas crian?as em tratamento.
Objetivo: Avaliar a fun??o pulmonar de crian?as com leucemia aguda. M?todo:
Trata-se de um estudo observacional do tipo anal?tico transversal. Foram avaliadas
34 crian?as, alocadas nos grupos A e B. O grupo A foi formado por 17 crian?as com
leucemia aguda na fase de manuten??o do tratamento quimioter?pico e o grupo B
por 17 estudantes saud?veis da rede p?blica do munic?pio de Natal/RN, pareados
em rela??o a g?nero, idade e altura. A mobilidade tor?cica foi avaliada por meio de
cirtometria tor?cica nos n?veis axilar e xif?ide. A espirometria foi mensurada
utilizando o espir?metro Microloop Viasys? seguindo as normas da ATS e ERS. As
press?es respirat?rias m?ximas foram mensuradas com o manovacu?metro digital
MVD300 (Globalmed?). As press?es inspirat?rias m?ximas (PIm?x) e as press?es
expirat?rias m?ximas (PEm?x) foram medidas a partir do volume residual e da
capacidade pulmonar total, respectivamente. Os dados foram analisados atrav?s do
software SPSS 17.0 atribuindo-se o n?vel de signific?ncia de 5%. A an?lise descritiva
foi expressa atrav?s de m?dia e desvio padr?o. Foi utilizado o teste t student n?o
pareado para compara??o dos valores encontrados no grupo A com os valores do
grupo B, bem como com os valores de refer?ncia utilizados. Para compara??o entre
os coeficientes respirat?rios no n?vel axilar com o n?vel xif?ide em cada grupo,
utilizou-se o teste t student pareado. Resultados: O grupo A apresentou diminui??o
significativa da mobilidade tor?cica e da PIm?x quando comparado ao grupo B, bem
como da PIm?x quando comparada aos valores de refer?ncia. N?o houve diferen?a
significativa entre os dados espirom?tricos dos dois grupos avaliados e os valores do
grupo A com os valores de refer?ncia de Mallozi (1995). Tamb?m n?o existiu
diferen?a significativa entre os valores de PIm?x e PEm?x e os valores de limites
inferiores propostos como refer?ncia por Borja (2011). Conclus?o: As crian?as com
leucemia aguda, linf?ide ou miel?ide, durante o per?odo de manuten??o do
tratamento quimioter?pico apresentam redu??o da mobilidade tor?cica e da for?a
muscular inspirat?ria. Entretanto, at? este momento, de conclus?o do tratamento
quimioter?pico, as vari?veis espirom?tricas e a for?a dos m?sculos expirat?rios
parecem manter-se preservadas em crian?as entre cinco e dez anos
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/16718 |
| Date | 05 January 2012 |
| Creators | Macedo, Thalita Medeiros Fernandes de |
| Contributors | CPF:72298863415, http://lattes.cnpq.br/1736384836028397, Fran?a, Danielle Corr?a, CPF:01281371696, http://lattes.cnpq.br/9690428784276877, Ferreira, Gard?nia Maria Holanda, CPF:21268843334, http://lattes.cnpq.br/4934425482168899, Mendon?a, Karla Morganna Pereira Pinto de |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Fisioterapia, UFRN, BR, Movimento e Sa?de |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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