Native heart valves that have limited functionality due to cardiovascular disease or congenital birth defects are commonly replaced by prosthetic heart valves. Bileaflet mechanical heart valves (BMHV) are the most commonly implanted valve design due to their long-term durability. However, their unnatural hemodynamics promote thrombosis and thromboembolic events. Clinical reports and in vitro experiments suggest that the thrombogenic complications in bileaflet valves are related to the stress imposed on blood by the valves during the closing phase. Additionally, animal and clinical studies have shown that BMHV in the aortic position demonstrate reduced failure rates compared to identical valves in the mitral position.
The present study aimed to investigate the leakage, hinge, and near hinge flow fields of two BMHV under simulated physiologic aortic flow conditions and to compare these results with previous findings in the mitral position to better understand how the implant location influences the valve performance and the subsequent risk of blood damage.
Two and three-component Laser Doppler Velocimetry techniques were used to quantify the velocity and turbulent shear stress fields in both the hinge and the upstream leakage flow regions. The study focused on the 23 mm St. Jude Medical Regent (SJM) and the 23 mm CarboMedics (CM) valves.
Although they were tested under similar physiologic conditions, shape and location of the leakage jets were dependent on valve design. Nevertheless, turbulent shear stress levels recorded within all jets were well above the threshold shear stress for the onset of blood cell damage. Within the hinge region, the flow fields were complex and unsteady. The angulated hinge recess of the CM valve appeared to promote blood damage while the streamlined geometry of the SJM valve contributed to better washout of the hinge region. Animations of the velocity flow fields are given in QuickTime or MPEG format. Comparison of the present findings with previously published results for the mitral position suggests that the superior clinical results of the mechanical valves in the aortic position may be due to less severe leakage flow upon valve closure as well as to enhanced hinge washout during the forward flow phase.
| Identifer | oai:union.ndltd.org:GATECH/oai:smartech.gatech.edu:1853/5159 |
| Date | 08 April 2004 |
| Creators | Simon, Helene A. |
| Publisher | Georgia Institute of Technology |
| Source Sets | Georgia Tech Electronic Thesis and Dissertation Archive |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
| Format | 522331 bytes, 617659 bytes, 615868 bytes, 602588 bytes, 457750 bytes, 578272 bytes, 535487 bytes, 534205 bytes, 419646 bytes, 611619 bytes, 925834 bytes, 1009631 bytes, 976930 bytes, 780180 bytes, 9091193 bytes, video/quicktime, video/quicktime, video/quicktime, video/quicktime, video/quicktime, video/quicktime, video/quicktime, video/quicktime, video/quicktime, video/quicktime, video/mpeg, video/quicktime, video/mpeg, video/quicktime, application/pdf |
Page generated in 0.0064 seconds