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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Clinical utility of the modified Wells score in combination with the D-dimer assay in the prediction of deep venous thrombosis in a local population

Goodier, Matthew 25 January 2013 (has links)
Clinical prediction scores such as the modified Wells score have proved useful to determine the likelihood for the presence of lower limb deep venous thrombosis (DVT). Infection with HIV may affect the validity of this approach in the South African context. This study of 230, mostly inpatients, of which 40% were HIV positive, confirms the validity of the modified Wells score in a South African population with a high HIV seroprevalence. The score was found to be most accurate when performed within 48 hours of initiation of anticoagulation therapy and when combined with D-dimer assay result. The more widespread utilisation of this score, especially in conjunction with the D-dimer assay as part of a diagnostic algorithm will make investigation of DVT simpler and more cost effective. A diagnostic algorithm previously proven to be cost effective is suggested for adoption in local clinical practice as well as a basis for future research.
2

The implications of molecular diagnostics in clinicopathologic correlations in two disease processes PSA serum levels in acute illnesses and prevalence of activated protein C resistance and Factor V mutation in patients with thrombosis and in control patients by ethnic group /

Honda, Stacey A. A. January 2002 (has links)
Thesis (Ph. D.)--University of Hawaii at Manoa, 2002. / Includes bibliographical references (leaves 62-71). Also available on microfiche.
3

Quasi-static Acoustic Tweezing for Small Volume Blood Coagulation Analysis

January 2019 (has links)
archives@tulane.edu / The activation of the coagulation cascade at artificial surfaces of container walls leads to inherent variability and unreliability in predicting bleeding or thrombosis risks. Large number of false results and a lack of standardization have caused concern in the medical community about the usefulness of photo-optical plasma coagulation tests such as PT/aPTT as well as whole blood viscoelastic methods. We have developed an integrated photo-optical / viscoelastic method for noncontact blood coagulation analysis. In this approach, referred to as “integrated quasi-static acoustic tweezing thromboelastometry” (i-QATT), temporal changes in blood elasticity and turbidity during coagulation are assessed from a single drop of blood levitating in air. i-QATT provides comprehensive information about blood coagulation including reaction time, kinetics of fibrin formation and cross-linking, clot firmness, fibrinolysis, and functional level of coagulation factors. This work demonstrates the ability of this method to rapidly and reliably measure the coagulation factor deficiency, functional levels of fibrinogen and factor XIII, platelet function, heparin dose response as well as identify bleeding / thrombotic risks in human subjects. i-QATT has been successfully used to detect the hypercoagulable state in smoking subjects. / 1 / Daishen Luo
4

Evaluation of plasminogen function in health and disease

Al-Hilali, Mahir Mohamad Ali January 1990 (has links)
No description available.
5

Laboratory control of anticoagulant therapy : an analysis of current dilemmas; heparin

Kitchen, S. January 1998 (has links)
No description available.
6

Protein S deficiency and familial thrombophilia

Simmonds, Rachel Elizabeth January 1997 (has links)
No description available.
7

Studies of the molecular structures of the blood coagulation fibrinolytic proteins

Brown, Anthony James Moginie January 1994 (has links)
No description available.
8

Role of von Willebrand factor in shear induced platelet accumulation in a microfluidic device

Casa, Lauren D. C. 08 June 2015 (has links)
Thrombus formation under high fluid shear rates at the site of atherosclerotic plaque rupture leads to myocardial infarction and stroke. At high shear rates, thrombus is formed by platelets adhering via the glycoprotein von Willebrand factor (vWF). To investigate the relative contributions of vWF and platelets in high shear thrombosis, the present work developed a microfluidic thrombosis assay to meet low blood volume requirements and fluid shear conditions (3500-6000 s-1). Microfluidic conditions were selected to mimic the high shear environment of a diseased coronary artery, with the long-term objective of developing a clinically relevant assay for the assessment of thrombosis risk and treatment efficacy. The microfluidic design also addressed the requirement for volumetric thrombus formation rather than only surface platelet adhesion. As part of the design of the microfluidic assay, the effect of flow pulsatility on high shear thrombosis was investigated. It was found that steady wall shear rate matched to the mean pulsatile wall shear rate reproduced bulk thrombus formation characteristics of occlusion time, lag time, and thrombus growth rate, allowing subsequent experiments and future device design to utilize steady flow. The microfluidic assay was implemented to study the roles of vWF and platelets to thrombus formation using blood analogs produced from whole human blood diluted with normal saline at 90% and 99%. Hematocrit was restored to normal in all cases with the addition of red blood cells, and vWF and platelets were selectively restored to normal levels. Results showed that 90% dilutions with only vWF restored to normal levels occluded in 6/7 subject tested. The addition of platelets accelerated thrombus formation, but blood analogs with only platelets restored to normal levels occluded in only 2/5 subjects, indicating that vWF is more contributory in high shear occlusive thrombosis. At 99% dilutions, large thrombus formed with the addition of both platelets and vWF but was unstable and did not fully occlude the channel, indicating the possible requirement of an additional stabilizing factor(s) in occlusive thrombosis. Results of this study may lead to the development of improved anti-thrombotic treatments and improve patient care by providing a potential assay to evaluate treatment effectiveness and predict thrombosis risk.
9

Assessment of fibrinolytic and antithrombotic activity resulting from modulation of endogenous fibrinolysis in animal models

Jamieson, Alec January 1993 (has links)
The primary aims of the project were: i) to develop assays capable of detecting changes in endogenous fibrinolytic activity for use in animal models. ii) to determine whether changes in endogenous fibrinolytic activity could be achieved following administration of a range of pharmacologically active agents. iii) to investigate the effect of such changes in endogenous fibrinolytic activity on thrombus formation and lysis in a suitable animal model <i>in vivo</i>. 1. Methods established for estimation of fibrinolytic activity in the plasma of rats and rabbit comprised chromogenic activity assays measuring tPA and PAI activity and the euglobulin clot lysis time assay as an index of fibrinolytic capacity. Changes in either plasma tPA or plasma PAI levels correlated well with changes in fibrinolytic activity as measured by the euglobulin clot lysis time assay; this comparison has previously not been carried out in animal studies. 2. A range of animal tests were investigated in an attempt to identify a paradigm of disease compromised fibrinolytic activity. Again, a systematic approach of this type had not previously been carried out in animals. The most significant alteration in plasma fibrinolytic activity was seen in the arthritic rabbit where levels of PAI and the acute phase reactant fibrinogen were significantly elevated. These data provide new evidence demonstrating PAI acting as an acute phase reactant in an animal model of inflammation. 3. Compounds were identified that either possessed pro-fibrinolytic actions (by elevating endogenous tPA activity or inhibiting endogenous PAI activity) or were shown to inhibit fibrinolytic activity (increased plasma PAI activity).
10

Thromboseprophylaxe mit niedrig dosiertem Dextran

Brader, Johannes Joachim, January 1979 (has links)
Thesis (doctoral)--Ludwig Maximilians-Universität zu München, 1979.

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