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Synovial fluid components as synergistic lubricants in articular joint models / Smörjningssynergier mellan komponenter i synovialvätska

The excellent lubrication present within mammalian synovial joints attracted scientific interest, and some close-to-realistic models were applied to study the mechanism in vitro. In this project, the synergistic lubrication of synovial fluid was investigated by using 1,2-Dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), hyaluronic acid (HA), and phosphate-buffered saline (PBS buffer) to mimic the synovial fluid. Lubrication by the model synovial fluid was studied using borosilicate glass specimens in Mini-Traction Machine (MTM). The experiments proved that the DPPC vesicle solution and mixed DPPC/HA solution had excellent lubrication ability, stemming both from adsorption of a lubricious layer at the surface of glass specimens and from presence of material reservoir available for repair of wear defects in the lubricious layer. Comparing the macroscale results obtained in this project by MTM with the results in previous studies on microscale by using AFM, we concluded that the microscale study of synergistic lubrication could predict macroscale results, even though some differences were detected due to limited possibilities for exact replication of experimental conditions at the two scales.

Identiferoai:union.ndltd.org:UPSALLA1/oai:DiVA.org:kth-266374
Date January 2019
CreatorsLi, Sixuan
PublisherKTH, Kemi
Source SetsDiVA Archive at Upsalla University
LanguageEnglish
Detected LanguageEnglish
TypeStudent thesis, info:eu-repo/semantics/bachelorThesis, text
Formatapplication/pdf
Rightsinfo:eu-repo/semantics/openAccess

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