In this recent study,1 the authors analyzed the metabolic gene essentiality scores from genome-wide loss of function CRISPR screens in 769 human cancer cell lines and noticed that TCA cycle-associated genes clustered in two separate groups: one forming the traditional TCA cycle and another related to a non-canonical TCA cycle module. They monitored both modules with elegant tracing studies using [U-13C]glucose which generates citrate labeled with two 13C atoms (M+2).
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:91310 |
| Date | 22 May 2024 |
| Creators | Mateska, Ivona, Alexaki, Vasileia |
| Publisher | Macmillan Publishers, part of Springer Nature |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 201, 10.1038/s41392-022-01060-5 |
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