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Previous issue date: 2006-07-11 / This study describes the epidemiological and clinical characteristics of hepatitis C in Feira de Santana, Bahia, Brazil. Among the objectives we sought to describe socio-demographic data, smoking, use of alcoholic drinks, anthropometric evaluation, diagnosis of disease, antiviral therapy and its results, risk factors, HIV or hepatitis B coinfection, hepatitis B vaccine efficacy and extrahepatic manifestations of hepatitis C. The data obtained relates to 175 patients followed in private and public health care institutes. Most patients were male (65,1%) with an age of 41 to 60 years (74,9%), mulattoes (66,9%), married (65,1%), living in the urban area (97,1%), with 12 or more years of education (53,7%), with family income less than five salaries (66,9%) and were followed in the public health system (64,0%). The proportion of cases of smoking, consumption of alcoholic drinks and overweight or obesity was 14,9%, 68,0% and 40,6%, respectively. Assessment of risk factors for HCV infection revealed ast history of reusing disposable syringes, sharing of manicure kits, surgery, digestive endoscopy, blood transfusions in 68,6%, 51,4%, 44,6%, 41,7% and 14,9% of the cases, respectively. All the patients had at least one risk factor identified. Definitive make-up was reckoned as a possible risk factor for viral infection. Around half of patients were waiting for achievement of liver biopsy or genotyping to initiate treatment. Among the patients submitted to antiviral therapy, almost half of them have not concluded the treatment. Genotypes 1, 3 and 2 were observed, respectively, in 54,3%, 21,1% and 4,6% of the patients. The favourable response of hepatitis B vaccine was determined in 29,8% of patients submitted to vaccination. HCV/HIV and HCV/HBV co-infection were observed in 3,4% and 2,9%, respectively. Extrahepatic manifestations were observed in 26,9% of the subjects. All the studied patients with hepatitis C had identifiable risk factor for viral transmission. Besides traditional risk factors, other contamination sources can be important as HCV risk factors. In this group, many patients were waiting for achievement of liver biopsy or genotyping to start antiviral therapy. HCV/HBV co-infection rate found in this study was similar to that described in the literature, whereas HCV/HIV co-infection rate was low to that related for others authors. / Neste estudo tipo s?rie de casos est?o descritas as caracter?sticas epidemiol?gicas e cl?nicas da hepatite C no munic?pio de Feira de Santana-BA. Dentre os objetivos, buscou-se descrever os dados sociodemogr?ficos, tabagismo, uso de bebidas alco?licas, avalia??o antropom?trica, diagn?stico da doen?a, terapia antiviral e seus resultados, fatores de risco, co-infec??o com v?rus HIV ou hepatite B, efic?cia da vacina??o contra hepatite B e manifesta??es extra-hep?ticas da hepatite C. Os dados obtidos referem-se a 175 pacientes acompanhados em institui??es de sa?de p?blicas e privadas. A maioria dos pacientes era do sexo masculino (65,1%), com idade entre 41 a 60 anos (74,9%), pardos (66,9%), casados (65,1%), procedentes da zona urbana (97,1%), com 12 ou mais de escolaridade (53,7%), renda familiar abaixo de cinco sal?rios m?nimos (66,9%) e acompanhados em institui??es p?blicas de sa?de (64,0%). A propor??o de casos de tabagismo foi de 14,9%, consumo de bebidas alco?licas 68,0% e sobrepeso ou obesidade 40,6%. Avalia??o dos fatores de risco da infec??o pelo v?rus da hepatite C mostrou que 68,6% tinham usado seringa de vidro
reutiliz?vel, 51,4% compartilhamento de material de manicure, 44,6% cirurgia, 41,7% endoscopia digestiva e 14,9% hemotransfus?o. Todos os pacientes apresentavam pelo menos um fator de risco. Maquiagem definitiva parece ser um fator de risco adicional para a infec??o viral. Cerca de metade dos pacientes estava esperando a realiza??o de bi?psia hep?tica ou genotipagem para iniciar a terapia antiviral.Entre os pacientes submetidos ? terapia antiviral, cerca de 50% ainda n?o tinham conclu?do o tratamento. Gen?tipo 1 foi observado em 54,3%, 3 em 21,1% e 2 em 4,6%.Resposta favor?vel ? vacina contra hepatite B foi descrita em 29,8% dos pacientes. Co-infec??o com o v?rus HIV e com o v?rus da hepatite B foi observada em 3,4% e 2,9%, respectivamente. Manifesta??es extra-hep?ticas foram observadas em 26,5%. Todos os pacientes avaliados apresentavam fator de risco relacionado ? infec??o viral. Al?m dos fatores de risco tradicionais, outras formas de contamina??o pelo v?rus da hepatite C parecem ser importantes. Neste grupo, muitos pacientes aguardavam a realiza??o de bi?psia hep?tica ou genotipagem para iniciar o tratamento antiviral. A freq??ncia de co-infec??o com o v?rus da hepatite B foi similar ao descrito na literatura, enquanto o percentual de co-infec??o com o v?rus HIV foi inferior ao observado por outros autores.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.uefs.br:8080:tede/30 |
| Date | 11 July 2006 |
| Creators | Maia, Karina Souza Ferreira |
| Contributors | Mendes, Jo?o Luiz Barberino |
| Publisher | UNIVERSIDADE ESTADUAL DE FEIRA DE SANTANA, Programa de P?s-Gradua??o em Sa?de Coletiva, UEFS, BR, Sa?de coletiva |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UEFS, instname:Universidade Estadual de Feira de Santana, instacron:UEFS |
| Rights | info:eu-repo/semantics/openAccess |
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